Search results: Found 6

Listing 1 - 6 of 6
Sort by
Epileptology - The Modern State of Science

Author:
ISBN: 9789535126980 9789535126997 Year: Pages: 278 DOI: 10.5772/61409 Language: English
Publisher: IntechOpen
Subject: Neurology --- Pediatrics
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

Epilepsy seems to represent one of the most frequent neurological diseases and occurs in about 1% of the general population. Although epilepsy is known since antiquity, the precise data on its pathogenesis and effective treatment are still collected and nowadays represents an interest for neurologists and psychiatrists. Being a neurological disease, epilepsy is characterized by a broad palette of comorbid psychiatric disorders (affective and anxiety disorders, psychoses) that reduce the quality of life. Moreover, the risk of suicidal attempts in persons with epilepsy is much higher than in general population that once again increases the actuality of epilepsy research in many aspects. The book contains 13 chapters written by different authors from all over the world on different topics, including phenomenology, pathogenesis, and treatment in epilepsy. The modern data on these topics may be helpful for many specialists in the domain of epileptology.

Cannabinoids in Health and Disease

Authors: ---
ISBN: 9789535124290 9789535124306 9789535141983 Year: Pages: 258 DOI: 10.5772/61595 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 09:47:09

Loading...
Export citation

Choose an application

Abstract

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

Toxicology - New Aspects to This Scientific Conundrum

Authors: ---
ISBN: 9789535127161 9789535127178 Year: Pages: 218 DOI: 10.5772/62600 Language: English
Publisher: IntechOpen
Subject: Public Health
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

This edited book, Toxicology - New Aspects to This Scientific Conundrum, is intended to provide an overview on the different xenobiotics employed every day in our anthropogenic activities. We hope that this book will continue to meet the expectations and needs of all interested in the implications for the living species of known and new toxicants and to guide them in the future investigations.

Special Topics in Drug Discovery

Authors: ---
ISBN: 9789535127994 9789535128007 Year: Pages: 190 DOI: 10.5772/62591 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 09:47:10

Loading...
Export citation

Choose an application

Abstract

Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.

The Physiology and Pharmacology of Leucine-rich Repeat GPCRs

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199587 Year: Pages: 115 DOI: 10.3389/978-2-88919-958-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2016-01-19 14:05:46
License:

Loading...
Export citation

Choose an application

Abstract

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within the transmembrane domains as well as extracellular and intracellular domains. One such family of Class A receptors is characterized by multiple leucine- rich repeats within their amino- terminal domains (the Leucine-rich Repeat family (LRR)). This family of GPCRs are best represented by the glycoprotein hormone receptors (LHR, FSHR and TSHR) which have been studied extensively but also includes receptors for the peptide hormone relaxin (RXFP1 and RXFP2 (RXFP2 also binds insulin-like peptide 3)) and three other receptors (LGR4, LGR5 and LGR6). LGR4-6 were, until recently, considered orphan receptors. However, emerging data have revealed that these proteins are the receptors for a family of growth factors called R-spondins. Over the last 20 years much has been learned about LRR receptors, including the development of synthetic agonists and antagonists, new insights into signaling (including signaling bias) and the physiological role these receptors play in regulating the function of many tissues. This topic will focus on what is known concerning the regulation of these receptors, their signaling pathways, functional consequences of activation and pharmacology.

Keywords

GPCR --- Leucine- rich repeat --- LH --- FSH --- TSH --- Relaxin --- R-spondin --- LRR --- Pharmacology

Anti-cancer Drugs - Nature, Synthesis and Cell

Author:
ISBN: 9789535128137 9789535128144 Year: Pages: 196 DOI: 10.5772/62959 Language: English
Publisher: IntechOpen
Subject: Pharmacy and materia medica
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

We are in constant search for new therapeutic options to cure cancer. In this book, you can find out how scientists throughout the world deal with this problem. Readers will learn how to engage nature, chemical synthesis, and cell machinery to design new anticancer agents. Nature has already been very generous in providing us different compounds which are in widespread application. Starting from these resources, various synthetic processes are applied to create synthetic drugs which can be then obtained in large quantities. Also, the cell by itself provides different possibilities to meet the constantly increasing requirements for successful therapy. Explore the book and find out what are the new ways to fight cancer.

Listing 1 - 6 of 6
Sort by
Narrow your search

Publisher

IntechOpen (5)

Frontiers Media SA (1)


License

unknown (5)

CC by (1)


Language

english (6)


Year
From To Submit

2016 (6)