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CHAPTER 5 ‘Rapt Up with Joy’: (Book chapter)

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Book Series: Palgrave Studies in the History of Childhood ISBN: 9781137571991 Year: Pages: 21 Language: English
Publisher: Springer Grant: Wellcome Trust
Subject: Sociology --- Social Sciences
Added to DOAB on : 2019-01-15 13:34:07
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This chapter takes advantage of recent insights from the history of&#xD;emotions to offer a fresh perspective on children’s emotional responses to&#xD;death. Drawing on a range of printed and archival sources, it argues that&#xD;children expressed diverse and conflicting emotions, from fear and anxiety,&#xD;to excitement and ecstasy. In contrast to Houlbrooke and Stannard, I&#xD;have found that children’s responses seem to have changed little over the&#xD;early modern period. This continuity is largely due to the endurance of&#xD;the Christian doctrine of salvation, with its hauntingly divergent fates of&#xD;heaven and hell.

Infection and Inflammation: Potential Triggers of Sudden Infant Deaths

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450497 Year: Pages: 94 DOI: 10.3389/978-2-88945-049-7 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2018-02-27 16:16:44
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There is a growing body of evidence that infectious agents or their products contribute to events leading to unexpected infant deaths. This issue summarizes the current information on the interactions between genetic background of the infant, environmental and developmental risk factors, and the microbial flora of the infant that could trigger lethal responses to common infections.

Maintenance of Genome Integrity: DNA Damage Sensing, Signaling, Repair and Replication in Plants

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198207 Year: Pages: 129 DOI: 10.3389/978-2-88919-820-7 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair. DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.

The Black Death and Later Plague Epidemics in the Scandinavian Countries: Perspectives and Controversies

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ISBN: 9788376560472 9783110368154 Year: Pages: 736 DOI: 10.1515/9788376560472 Language: English
Publisher: De Gruyter
Subject: History
Added to DOAB on : 2017-01-18 15:15:40
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This monograph represents an expansion and deepening of previous works by Ole J. Benedictow - the author of highly esteemed monographs and articles on the history of plague epidemics and historical demography. In the form of a collection of articles, the author presents an in-depth monographic study on the history of plague epidemics in Scandinavian countries and on controversies of the microbiological and epidemiological fundamentals of plague epidemics.

Current Trends in Historical Sociolinguistics

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ISBN: 9783110488401 9783110488449 Year: Pages: 280 DOI: 10.1515/9783110488401 Language: English
Publisher: De Gruyter
Subject: Linguistics
Added to DOAB on : 2017-01-18 15:35:04
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The volume collects original studies highlighting contemporary trends in historical sociolinguistics, as well as current research on the relationship between sociolinguistics and historical linguistics, social motivations of language variation and change, and corpus-based studies. Distinctive features of the book, which make it appealing to a wider audience, are the interdisciplinary nature of the chapters and the range of languages addressed.

Sensory Hair Cell Death and Regeneration

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450008 Year: Pages: 266 DOI: 10.3389/978-2-88945-000-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future.

D. Pedro e D. Inês: diálogos entre o amor e a morte

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Book Series: Outros Títulos ISBN: 9789892611594 Year: Pages: 118 DOI: https://doi.org/10.14195/978-989-26-1160-0 Language: Portuguese
Publisher: Coimbra University Press
Added to DOAB on : 2019-04-23 16:21:06
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The famous translation of Inês de Castro’s body from Coimbra to Alcobaça, in 1361, and its deposition in the beautiful tomb that future generations, ever since then, never ceased to admire at the Monastery of Alcobaça reached its climax in a beautiful and emotional discourse: the "Sermon in the funeral of D. Inês de Castro," by D. João de Cardaillac, Archbishop of Braga, whose eloquence and oratory had earned him the most noble and prominent position of official speaker at the papal court in Avignon. Scientific knowledge is combined with rhetorical proficiency to justify, by solid legal and religious arguments, the validity of D. Pedro’s marriage with D. Inês and the licitness of their loves. This work presents a study on the implications of the sermon and its historical circumstances as well as its critical edition and translation, together with a philological commentary, in order to provide a solid study that meets the needs that experts in a broad range of scientific fields had already expressed, without neglecting, however, the interests of non-academic audiences.

Golgi Pathology in Neurodegenerative Diseases

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197576 Year: Pages: 119 DOI: 10.3389/978-2-88919-757-6 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses.

Human Remains in Society

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Book Series: Human Remains and Violence ISBN: 9781526107381 9781526129338 Year: Language: English
Publisher: Manchester University Press Grant: Knowledge Unlatched - 100901
Subject: Anthropology
Added to DOAB on : 2018-02-21 11:02:20
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Whether reburied, concealed, stored, abandoned or publicly displayed, human remains raise a vast number of questions regarding social, legal and ethical uses by communities, public institutions and civil society organisations. This book presents a ground-breaking account of the treatment and commemoration of dead bodies resulting from incidents of genocide and mass violence. Through a range of international case studies across multiple continents, it explores the effect of dead bodies or body parts on various political, cultural and religious practices. Multidisciplinary in scope, it will appeal to readers interested in this crucial phase of post-conflict reconciliation, including students and researchers of history, anthropology, sociology, archaeology, law, politics and modern warfare.

Immunogenic Cell Death in Cancer: From Benchside Research to Bedside

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198382 Year: Pages: 145 DOI: 10.3389/978-2-88919-838-2 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Oncology
Added to DOAB on : 2017-02-07 16:12:31
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Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.

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