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The Vestibular System in Cognitive and Memory Processes in Mammals

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197446 Year: Pages: 246 DOI: 10.3389/978-2-88919-744-6 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Since the beginning of life, all plant and animal kingdoms have been developed or modified based on gravity along with atmospheric composition and solar radiation existing on Earth. Gravity is mainly encoded by the otolithic sensors of the vestibular system but its role has been largely underestimated in favor of the vestibular semicircular canals and reduced to oculomotor and postural coordination. Over the last decade, it has been demonstrated that sensory information provided by the vestibular system is crucial in spatial-memory processes in rats and humans. More recently a role in attention processes has been raised. This topic aims to report and demonstrate the role and integration of vestibular information in cognitive processes in rodent models and human at the behavioral, imaging and electrophysiological levels.

Hormonal and Neuroendocrine Regulation of Energy Balance

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198856 Year: Pages: 117 DOI: 10.3389/978-2-88919-885-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2016-01-19 14:05:46
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Alteration in adequate energy balance maintenance results in serious disturbances such as obesity and its related metabolic disorders. In Mammals, energy balance is homeostatically controlled through hormonal and neuroendocrine systems which cooperation is based on cross-talk between central and peripheral signals. The hypothalamus as well as peripheral hormones among which adipokines from adipose tissue and thyroid hormones play a crucial role in energy homeostasis. Unraveling the physiological, cellular and molecular mechanisms through which hormonal and neuroendocrine systems regulate energy balance has been a long-standing challenge in biology and is now more necessary when considering the world-wide increasing prevalence of obesity. Indeed, recognizing and understanding the biochemical and nutrient signaling pathways contributing to the nervous and endocrine integration of physiological mechanisms involved in the normal and/or abnormal regulation of energy balance is fundamental also to the development of new, effective, and targeted treatments for obesity. Recent studies have highlighted the role of hypothalamic pro-opiomelanocortin-expressing neurons in the regulation of energy homeostasis by controlling energy expenditure and food intake. This is accomplished through a precise balance of production and degradation of a-melanocyte-stimulating hormone, an anorexigenic neuropeptide which is degraded to an inactive form unable to inhibit food intake by the key enzyme prolyl carboxypeptidase (PRCP), thus suggesting that pharmacologic approaches targeting PRCP may provide a novel and effective option for the management of obesity and its associated metabolic disorders. Indeed, efforts have been made to generate potent, brain-penetrant PRCP inhibitors. Weight loss due to negative energy balance is a goal for obese subjects not always reachable by dietary caloric restriction or increased physical activity. Lipid-lowering therapies have been suggested to have potential benefits, however, the establishment of comprehensive therapeutic strategies is still awaited. Recently, it has been reported that thyroid hormone (TH)- derivatives such as 3,5-diiodothyronine and 3-iodothyronamine possess interesting biological activities, opening new perspectives in thyroid physiology and TH derivatives therapeutic usage. Moreover, several studies, focusing on the interaction between thyroid hormone (TH), the autonomic nervous system and the liver, revealed an important role for the hypothalamus in the differential effects of TH on autonomic outflow to peripheral organs controlling energy balance. This Research Topic aims to give a comprehensive and integrate view of the factors involved in the endocrine and neuroendocrine signaling in energy balance regulation to highlight their involvement into physiological processes and regulatory systems as well as their perturbation during pathological processes.

The two-way link between eating behavior and brain metabolism

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197057 Year: Pages: 197 DOI: 10.3389/978-2-88919-705-7 Language: English
Publisher: Frontiers Media SA
Subject: Psychology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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This research topic collected and connected information concerning both the underlying metabolic mechanisms and consequences of eating behaviors. These two aspects are tremendously important for a better understanding of eating behavior abnormalities as well as for improving education on eating disorders and behaviors.

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