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A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2

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ISBN: 9789535128373 9789535128380 Year: Pages: 210 DOI: 10.5772/62743 Language: English
Publisher: IntechOpen
Subject: Biology
Added to DOAB on : 2019-10-03 07:51:49

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Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Actinobacteria - Basics and Biotechnological Applications

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ISBN: 9789535122487 Year: Pages: 400 DOI: 10.5772/60457 Language: English
Publisher: IntechOpen
Subject: Animal Sciences --- Microbiology
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This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.

Tumor Metastasis

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ISBN: 9789535126300 9789535126317 9789535141815 Year: Pages: 266 DOI: 10.5772/61798 Language: English
Publisher: IntechOpen
Subject: Oncology
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Metastasis is the major cause of cancer-related death. It is a multistep process. The mechanism underlying metastasis is complicated and poorly understood. Recent advances in tumor metastasis research have led to improved diagnosis and clinical management of cancer. However, new strategies on metastasis treatment are urgently needed, especially the novel biomarkers discovery and targeted therapy. This book is designed to present the most recent advances in tumor metastasis.

Free Radicals and Diseases

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ISBN: 9789535127468 9789535127475 9789535141655 Year: Pages: 386 DOI: 10.5772/61358 Language: English
Publisher: IntechOpen
Subject: Oncology
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The current volume entitled, ""Free Radicals and Diseases"" integrates knowledge in free radical-associated diseases from the basic level to the advanced level, and from the bench side to bed side. The chapters in this book provide an extensive overview of the topic, including free radical formations and clinical interventions.

Autophagy in Current Trends in Cellular Physiology and Pathology

Authors: ---
ISBN: 9789535127260 9789535127277 9789535141525 Year: Pages: 526 DOI: 10.5772/61911 Language: English
Publisher: IntechOpen
Subject: Cytology
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Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

Telomere - A Complex End of a Chromosome

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ISBN: 9789535127529 9789535127536 9789535141501 Year: Pages: 226 DOI: 10.5772/60625 Language: English
Publisher: IntechOpen
Subject: Genetics
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This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as ""telomeres"" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Cryopreservation in Eukaryotes

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ISBN: 9789535127796 9789535127802 9789535141433 Year: Pages: 228 DOI: 10.5772/62605 Language: English
Publisher: IntechOpen
Subject: Cytology
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Since accidentally discovering the ability of glycerol on protecting cells from freezing damage, many researchers have been pursuing to develop cryopreservation methods of a very wide range of cells and some tissues, and these have found widespread applications in biology and medicine. From the point of view of living organisms, cryopreservation is a useful tool for ex situ conservation of genetic resources together with its contribution on conservation of their biodiversity. Cryopreservation in Eukaryotes includes totally 12 chapters, which have been written by the expert researchers in the field. The chapters are a comprehensive collection of the most frequently used methods for eukaryotes. With this book, every researcher will better understand the principles, background, and current status of cryopreservation in particular organisms.

Microsatellite Markers

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ISBN: 9789535127970 9789535127987 Year: Pages: 252 DOI: 10.5772/62560 Language: English
Publisher: IntechOpen
Subject: Genetics
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Microsatellite or so-called simple sequence repeat (SSR) markers have been one of the most reliable molecular markers derived from the DNA molecule, which were widely and successfully used for more than 25 years in the genetic studies of environmental, agricultural, and biomedical sciences. The objective of this Microsatellite Markers book is to rehighlight and provide some updates on previous and recent utilization of microsatellite markers for various applications in agriculture and medicine, which void emerging opinion on ""full death"" of microsatellites as useful genetic markers. Chapters presented here demonstrate the future benefit of SSRs in many genetic studies as well as disease diagnosis and prognosis.

Metabolomics - Fundamentals and Applications

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ISBN: 9789535128533 9789535128540 Year: Pages: 216 DOI: 10.5772/62614 Language: English
Publisher: IntechOpen
Subject: Cytology
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Metabolomics: Fundamentals and Applications authoritatively presents the basic principles and applications of metabolomics. Topics covered in this book range from the analysis of metabolites from different biological sources and their data processing and statistical analysis. This book serves as a basic guide for a wide range of audiences from less familiar with metabolomics techniques to more experienced researchers seeking to understand complex biological systems from the systems biology approach.

Bioinformatics - Updated Features and Applications

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ISBN: 9789535125464 9789535125471 9789535141921 Year: Pages: 268 DOI: 10.5772/61421 Language: English
Publisher: IntechOpen
Subject: Biology
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An interdisciplinary bioinformatics science aims to develop methodology and analysis tools to explore large-volume of biological data using conventional and modern computer science, statistics, and mathematics, as well as pattern recognition, reconstruction, machine learning, simulation and iterative approaches, molecular modeling, folding, networking, and artificial intelligence. Written by international team of life scientists, this Bioinformatics book provides some updates on bioinformatics methods, resources, approaches, and genome analysis tools useful for molecular sciences, medicine and drug designs, as well as plant sciences and agriculture. I trust chapters of this book should provide advanced knowledge for university students, life science researchers, and interested readers on some latest developments in the bioinformatics field.

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2016 (13)