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Glial Plasticity in Depression

Authors: --- --- --- --- et al.
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199990 Year: Pages: 99 DOI: 10.3389/978-2-88919-999-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment.

Fatigue in Multiple Sclerosis

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197637 Year: Pages: 87 DOI: 10.3389/978-2-88919-763-7 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Medicine (General)
Added to DOAB on : 2016-04-07 11:22:02
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Dear Readers,If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.

Omega-3 Fatty Acids in Health and Disease

ISBN: 9783038422723 9783038422730 Year: Pages: XII, 312 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2016-11-11 19:02:10
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The role of major dietary omega-3 fatty acids (Ω-3; α-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) in human health has generated enormous scientific interest and many controversies in recent years. Due to a growing number of studies with conflicting or even negative clinical results, the former “hype” of Ω-3 thought to be beneficial in many aspects of human health regardless of the physiological and clinical preconditions is now being critically re-evaluated, especially with respect to the potential role of Ω-3 fatty acid supplementation in preventing a variety of diseases and clinical conditions. This critical view reflects the complex interaction of Ω-3 with cell membranes and their integrated proteins mediating signal transduction, transport systems, and other processes. Moreover, Ω-3 are precursors of bioactive metabolites, such as eicosanoids, lipoxins, resolvins, protectins, maresins, and nitrolipids that influence several physiological and pathophysiological processes and their full spectrum of effects are only beginning to be defined. Finally, physiological and pathophysiological conditions as well as concomitant pharmacological treatments may influence the specific and non-specific actions of Ω-3 supplementation.This Special Issue of the Journal of Clinical Medicine will emphasize the role and biological interactions of Ω-3 with regard to cancer, psychiatric disorders, metabolic disorders and nutrition and will also reflect on some basic molecular and cellular mechanisms.

American Mobilities

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Book Series: American Culture Studies ISBN: 9783837634556 9783839434550 Year: Language: English
Publisher: transcript Verlag Grant: Knowledge Unlatched - 101244
Subject: Social Sciences
Added to DOAB on : 2018-03-16 11:02:30
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American Mobilities investigates representations of mobility – social, economic, geographic – in American film and literature during the Depression, WWII, and the early Cold War. With an emphasis on the dual meaning of »domestic«, referring to both the family home and the nation, this study traces the important trope of mobility that runs through the »American« century. Juxtaposing canonical fiction with popular, and low-budget independent films with Classical Hollywood, Leyda brings the analytic tools of American cultural and literary studies to bear on an eclectic array of primary texts as she builds a case for the significance of mobility in the study of the United States.

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