Search results: Found 4

Listing 1 - 4 of 4
Sort by
Innovative Medicine: Basic Research and Development

Authors: --- ---
ISBN: 9784431556503 9784431556510 Year: Pages: 339 DOI: 10.1007/978-4-431-55651-0 Language: English
Publisher: Springer
Subject: Medicine (General)
Added to DOAB on : 2016-06-30 12:46:49
License:

Loading...
Export citation

Choose an application

Abstract

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Ranaviruses: Lethal Pathogens of Ectothermic Vertebrates

Authors: ---
ISBN: 9783319137544 9783319137551 Year: Pages: 246 DOI: 10.1007/978-3-319-13755-1 Language: English
Publisher: Springer
Subject: Therapeutics --- Biotechnology --- Microbiology
Added to DOAB on : 2016-04-12 15:59:14
License:

Loading...
Export citation

Choose an application

Abstract

This is the first book on ranaviruses. Ranaviruses are double-stranded DNA viruses that cause hemorrhagic disease in amphibians, reptiles, and fish. They have caused mass die-offs of ectothermic vertebrates in wild and captive populations around the globe. There is evidence that this pathogen is emerging and responsible for population declines in certain locations. Considering that amphibians and freshwater turtles are suitable hosts and the most imperiled vertebrate taxa in the world, ranaviruses can have significant impacts on biodiversity and ecosystem function. Additionally, many fish that are raised in aquaculture facilities and traded internationally are suitable hosts; thus, the potential economic impact of ranaviruses is significant. Ranaviruses also serve as a model for replication and gene function of large double-stranded DNA viruses. There is an urgent need to assemble the contemporary information on ranaviruses and provide guidance on how to assess their threats in populations. Through the Global Ranavirus Consortium, 24 experts from six countries were organize to write this volume, the first book on ranaviruses. The book begins with a discussion on the global extent of ranaviruses, case histories of infection and disease in ectothermic vertebrates, and current phylogeny. Basic principles of ranavirus ecology and evolution are covered next, with a focus on host-pathogen interactions and how the virus emerges in its environment. There are two chapters that will discuss the molecular biology of ranaviruses, host response to infection, and the genes responsible for immune system evasion. One chapter establishes standards for testing for infection and diagnosing ranaviral disease. The book ends by providing guidance on how to design ranavirus surveillance studies and analyze data to determine risk, and discussing the role of the Global Ranavirus Consortium in organizing research and outreach activities.

High Density Lipoproteins: From Biological Understanding to Clinical Exploitation

Authors: ---
Book Series: Handbook of Experimental Pharmacology ISSN: 01712004 ISBN: 9783319096643 9783319096650 Year: Volume: 224 Pages: 694 DOI: 10.1007/978-3-319-09665-0 Language: English
Publisher: Springer
Subject: Manufactures --- Electrical and Nuclear Engineering --- Chemical Technology --- Business and Management --- Biotechnology --- Therapeutics --- Medicine (General)
Added to DOAB on : 2015-07-20 15:18:00
License:

Loading...
Export citation

Choose an application

Abstract

n this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

Impacts of the Fukushima Nuclear Accident on Fish and Fishing Grounds

Authors: ---
ISBN: 9784431555360 9784431555377 Year: Pages: 238 DOI: 10.1007/978-4-431-55537-7 Language: English
Publisher: Springer
Subject: Aquaculture and Fisheries --- Business and Management --- Chemical Engineering
Added to DOAB on : 2016-06-27 16:32:42
License:

Loading...
Export citation

Choose an application

Abstract

This book presents the results from the Japanese Fisheries Research Agency’s 3-year intensive monitoring of radionuclides in a variety of fish, plankton, benthos, and their living environments after the Fukushima Daiichi Nuclear Power Plant (FNPP) accident in March 2011. The book reveals the dynamics of contamination processes in marine and freshwater fish, mediated by the contamination of water, sediments, and food organisms; it also clarifies the mechanisms by which large variations in the level of contamination occurs among individual fish. Most importantly, the book includes a large amount of original measurement data collected in situ and for the first time assesses diffusion of radiocesium across the Pacific using both in situ data and a numerical simulation model. Also introduced are several new approaches to evaluate the impact of the release of radionuclides, including the measurement of radiation emission from an otolith section to identify the main period of contamination in fish. The FNPP accident represents a rare instance where the environmental radioactivity level was elevated steeply through atmospheric fallout and direct discharge of radioactive water into the sea over a short period of time. Replete with precise scientific data, this book will serve as an important resource for research in fields such as fishery science, oceanography, ecology, and environmentology, and also as a solid basis for protecting fisheries from damage resulting from harmful rumors among the general public.

Listing 1 - 4 of 4
Sort by
Narrow your search

Publisher

Springer (4)


License

CC by-nc (4)


Language

english (4)


Year
From To Submit

2015 (4)

-->