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Spatial memory - a unique window into healthy and pathological ageing

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193868 Year: Pages: 122 DOI: 10.3389/978-2-88919-386-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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The global population aged over 60 is set to rise dramatically in the coming decades. In many countries, the older population now faces the prospect of spending a quarter of their lives aged over 65, and a significant proportion will have to cope with cognitive decline associated with normal ageing or with dementia disorders. Given that these fundamental demographic changes will pose a significant challenge to health care systems, a detailed understanding of age-related cognitive and neurobiological changes is essential in helping elderly populations maintain cognitive performance. In addition, developing sensitive biomarkers to identify those at risk of developing dementia is crucial for early and effective interventions. To make inferences about the ageing process from the animal model back to the human, rigorous behavioral paradigms must be used to ensure that the same function is being examined across species. Given that similar navigational paradigms can easily be applied to humans and animals, recent years have seen an expansion of studies attempting to bridge the gap between age-related changes in animal and human spatial cognition. These studies begin to suggest that disruptions in spatial computations are among the earliest indicators of impending cognitive decline. In addition, although many animal studies have identified pathological mechanisms with paradigms involving spatial navigation, these mechanisms support many nonspatial cognitive functions as well. As a consequence, a successful characterization of how spatial processing changes in the ageing brain could reveal fundamental effects of cognitive ageing that could inform about general mechanisms underlying decline in perception, mnemonic processing and multisensory integration.

Desapariciones forzadas de niños en Europa y Latinoamérica: del convenio de la ONU a las búsquedas a través del ADN

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Book Series: Col·lecció de Bioètica ISBN: 9788447538522 Year: Pages: 368 Language: Spanish
Publisher: Publicacions i Edicions de la Universitat de Barcelona
Subject: Philosophy --- Medicine (General) --- Public Health
Added to DOAB on : 2018-10-15 14:38:16
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Los análisis genéticos y el convenio de la ONU contra las desa­pariciones forzadas son dos poderosas herramientas que per­miten esclarecer los orígenes biológicos y luchar contra el robo de bebés y las desapariciones forzadas de niños. Estos delitos, de una gravedad manifiesta, requieren ser examinados desde sus vertientes jurídica, filosófica, política y bioética, porque, ante una situación tan compleja y que afecta a tantas personas, una so­ciedad responsable está obligada a tomar medidas. El presente libro, que analiza estas cuestiones tanto en el contexto europeo como en el latinoamericano, es obra de especialistas vinculados a las instituciones y los comités más representativos en la materia.

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