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Animal model studies on viral infections

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194568 Year: Pages: 173 DOI: 10.3389/978-2-88919-456-8 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies.Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always.

Prozessentwicklung eines industrietauglichen Verfahrens zur Fertigung von vereinzelten LIGA-Mikrobauteilen

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Book Series: Schriften des Instituts für Mikrostrukturtechnik am Karlsruher Institut für Technologie / Hrsg.: Institut für Mikrostrukturtechnik ISSN: 18695183 ISBN: 9783731503262 Year: Volume: 30 Pages: VII, 211 p. DOI: 10.5445/KSP/1000045013 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
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This work deals with the development of an industry suited process aiming on the fabrication (based on the LIGA technique) of near net shape, single microparts. Those microparts should lead to new innovative ideas and thus to successful products on the market.

Kaposi's Sarcoma-Associated Herpesvirus

ISBN: 9783038420774 9783038420767 Year: Pages: 356 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 09:09:45
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The discovery of KSHV in 1994 was a historical landmark in tumor virology and human cancer research. Its subsequent identification as a cause of Kaposi sarcoma and in association with primary effusion lymphoma and multicentric Castleman disease soon attracted up to hundreds of research laboratories and thousands of virologists and oncologists to switch their research directions. To date, PubMed has collected nearly 5000 papers on KSHV from numerous journal publications in the world. These studies reiterate that the global fight against human cancers will continue to receive great support from our tremendous efforts in searching for new tumor-causing viruses and in understanding the basic biology of tumor viruses. To celebrate the 20th years of KSHV discovery, I am very proud to be an invited Guest Editor for a special issue on KSHV in the journal "Viruses" and happy to assemble all published articles from the special issue into this book, Kaposi Sarcoma Associated Herpesvirus. The collected articles cover almost all aspects of KSHV, including updated reviews and research articles on KSHV epidemiology and transmission, KSHV interaction with host cell receptors and cell entry, KSHV latency and latency-associated nuclear antigen (LANA), molecular biology of KSHV lytic reactivation and lytic switch control by KSHV ORF50 and other factors, KSHV post-transcriptional regulator ORF57, molecular biology of KSHV polyadenylated nuclear RNA (PAN RNA) and PAN as a lncRNA in epigenetic gene regulation of KSHV, viral mimics of cellular genes in KSHV infection and disease, KSHV targeted therapy, KSHV miRNAs and vGPCR, etc. In particular, I am greatly honored to have Yuan Chang and Patrick Moore to mark the first 20 years of KSHV research by recounting the historical stories leading to their astonish discovery and Science publication of KSHV that has led us where we are today. The book is also intended to assist Medical students and residents, dermatologists, hematologist, oncologists, and other related specialties to understand what we have known about KSHV and its infections and pathogenesis.

Stem Cell Genetic Fidelity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194902 Year: Pages: 110 DOI: 10.3389/978-2-88919-490-2 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General) --- Oncology --- Medicine (General)
Added to DOAB on : 2015-11-16 15:44:59
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The vision of this Frontiers in Oncology Research Topic on "Stem Cell Genetic Fidelity" had the goal of steeping a diverse range of research perspectives to a first comprehensive synthesis of thought on the questions of how tissue stem cells manage gene mutation rate and the significance of that management in mammalian evolution and biology, in particular as it relates to tissue cell renewal, carcinogenesis, and aging. The primary focus was determinants of mutation rate in distributed stem cells (DSCs), which encompass all naturally occurring stem cells at all stages of mammalian development. In particular, contributions were sought that considered a broad range of aspects of the immortal DNA strand hypothesis for DSC genetic fidelity. Though proposed in 1975, only in the last decade has this landmark concept in tissue cell biology emerged as a central discussion in DSC research with increasing scrutiny and discussion by an increasing number of laboratories of diverse research perspectives and experimental approaches. With this hypothesis presenting a formidable technical challenge for experimental investigation, as would be expected, both supportive and unsupportive reports have been lining up. In the case of supportive studies, neither the range of applicable tissues nor the responsible molecular mechanisms are known; and the essential genomic process, non-random DNA template strand inheritance by asymmetrically self-renewing DSCs, has been suggested to potentially have other cellular roles besides reducing mutation rate. A major aspiration of this Research Topic was to create the first comprehensive, critical synthesis of current insights and viewpoints on the impact of the immortal DNA strand hypothesis in the history of DSC mutation research. A wide range of article types was considered including historical perspectives, critical reviews, critical commentaries, new hypotheses, new research perspectives, technical advances, and original research reports. Although treatments of the immortal DNA strand hypothesis were the major focus, the desired synthesis required integration of related ideas on mechanisms of DSC mutagenesis and its impact in the evolution of mammals, the emergence of cancers, and stem cell aging. As such, investigators focused on issues in e.g., germ stem cell mutagenesis, effects of environmental mutagens on DSC mutation rate, DSC mutation and tissue aging, determinations of types of mutations in DSCs, and the role of DSC mutation in cancer initiation were invited. Similarly, although the specific goal of the Research Topic was to enlighten DSC genetic fidelity in humans and other mammalians, informing contributions based on studies in other model organisms were also welcomed. To achieve even better representation of current experience, advances, and ideas in this field of investigation, these early contributors were encouraged to extend the opportunity to others who shared their interest in advancing our understanding of the mutability of DSCs and its significance in human biology.

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