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Good News - Bad News: The Two Faces of Immune Privilege

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193318 Year: Pages: 109 DOI: 10.3389/978-2-88919-331-8 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:32
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Abstract

Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.

Entwurf eines fehlertoleranten Lenkventils für Steer-by-Wire Anwendungen bei Traktoren

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Book Series: Karlsruher Schriftenreihe Fahrzeugsystemtechnik / Institut für Fahrzeugsystemtechnik ISSN: 18696058 ISBN: 9783731502647 Year: Volume: 26 Pages: XII, 186 p. DOI: 10.5445/KSP/1000043068 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:02
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In this thesis a hydrostatic steer-by-wire valve with independent metering edges is analysed regarding its usability in safety critical applications. Doing experimental investigations it is shown, that valve faults can be compensated by the system in order to guarantee the steerability. Because of the chosen valve concept and the fact that valve faults can be detected without position sensors at each valve, the system complexity of the chosen solution is low.

Microbial mechanisms of tolerance to weak acids: an overview

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193059 Year: Pages: 91 DOI: 10.3389/978-2-88919-305-9 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Carboxylic acids are ubiquitous molecules found in microbial metabolic pathways and that have been explored for a wide array of applications including food preservation (e.g., acetic, propionic, benzoic, and sorbic acids), chemotherapy (e.g., the analgesic acetylsalicylic acid, the immunosuppressor mycophenolic acid or the antimalarial drugs artesunic and artemisinic acids) or agriculture (e.g., the herbicides 2,4-dichlorophenoxyacetic acid). This Research Topic contributes to the understanding of the molecular mechanisms underlying adaptation to weak acid stress in microbes, a knowledge base that impacts the fields of Medicine, Health, Food Safety and the Environment.

Heimatrecht und Staatsbürgerschaft österreichischer Juden

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ISBN: 9783205794950 Year: Pages: 290 DOI: 10.26530/oapen_461430 Language: German
Publisher: Böhlau Grant: Austrian Science Fund - PUB 81
Subject: History
Added to DOAB on : 2013-12-06 22:31:37
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The study describes the process of gradual inclusion of the Jews into the ‚Heimatrecht‘ and citizenship in the Austrian monarchy since the Josephine reforms. The stony path of integration of the Jews into general citizenship which spans centuries and is marked by numerous setbacks allows to shed new light on the act of expatriation of the Austrian Jews during the Nazi regime.The stony path of integration of the Jews into general citizenship spans many centuries and is marked by numerous setbacks. It stretches from special royal protection of the Jews ('Judenregal') via Tolerance or 'Familienstelle' all the way to full citizenship. A description of this development allows to shed new light on the previously dimly lit act of expatriation of the Austrian Jews during the Nazi regime. 

This was a complex process running in several stages which, although similar to the rest of the German Reich, occurred at a somewhat later stage and already under the sign of flight and expulsion. However, the disenfranchisement and – literally and legally - depersonalization of the Austrian Jews was - so the argument - not just an act of targeted Nazi persecution, but the systematic reversal in rapid motion of the Jews' emancipation which had started at the end of the 18th century. 

What at first glance appears to have been an abstruse and cluttered convolution of Nazi regulatory activity turns out, on closer analysis, to have been a meticulous reversal of the historical process of 'Jewish emancipation'. Numerous case studies and three major biographical studies towards the end of the book show to what extent the 'Heimatrecht' and citizenship or, by contrast, the fate of statelessness determined the lives and identities of people - far beyond the time of the Austrian monarchy.

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