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Drug Discovery and Development - Present and Future

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ISBN: 9789533076157 Year: Pages: 542 DOI: 10.5772/1179 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:48

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Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Tatort Gesundheitsmarkt - Rechtswirklichkeit - Strafwürdigkeit - Prävention

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Book Series: Göttinger Studien zu den Kriminalwissenschaften ISBN: 9783863950286 Year: Pages: 136 DOI: 10.17875/gup2011-132 Language: German
Publisher: Universitätsverlag Göttingen
Subject: Medicine (General) --- Law --- Pharmacy and materia medica
Added to DOAB on : 2012-04-11 21:20:13
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Reports on medical billing frauds, “premiums” of hospitals (for the referral of a patient) as well as the “medical marketing” arouse increasing attention in times of dwindling financial resources within the socially insured healthcare system and the worry for spreading “rationing”. Out of consideration for the partly remarkably high financial damages the call for a harsh punishment suggests itself, but the criminal law is always late and, above all, isn't capable of compensating the intangible loss of trust. Therefore, the search for instruments of an effective prevention of corruption deserves far more notice, but consequently the question of the real criminal events and of the possible “adjusting screws” for preventive interventions as well. The articles in this volume, which come from the recent (organized on 8 July 2011) annual conference of the Institute of Criminal Law and Justice in Göttingen, present the latest findings available so far. They may provide the interested public with an insight, that is respectably and not clouded by the drive of mass-media scandalisation, into the extent and appearances of corrupt behaviour in the healthcare system and may give the experts suggestions for productive further discussions and innovative problem solvings.

Drug Development - A Case Study Based Insight into Modern Strategies

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ISBN: 9789533072579 Year: Pages: 656 DOI: 10.5772/2435 Language: English
Publisher: IntechOpen
Subject: Therapeutics
Added to DOAB on : 2019-10-03 07:51:48

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This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.

Disposable Bioprocessing Systems

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ISBN: 9781439866702 Year: DOI: 10.1201/b11472 Language: English
Publisher: Taylor & Francis
Subject: Medicine (General) --- Agriculture (General)
Added to DOAB on : 2020-09-01 00:03:57
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Because of many misconceptions, the biological drug manufacturing industry does not fully utilize disposable components, despite their wide availability. These misconceptions include concerns for the quality of materials, running costs, scalability, the level of automation possible, and the training of staff needed to include these components in existing bioprocessing systems. Not fully realizing the long-term benefits, many manufacturers are unwilling to discard investments made in fixed equipment and traditional stainless steel systems. Regulatory and environmental concerns, however, will eventually compel manufacturers to adopt disposable systems. Making a strong case for disposables, Disposable Bioprocessing Systems demonstrates the true potential of these systems. Written by a researcher and professor with hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide, and creating model facilities using maximum disposable technology, this book is the first comprehensive introduction to understanding disposable systems. It gives an overview of the current state of the disposable bioprocessing industry, resolves all controversial issues, and guides readers in choosing disposable components that meet their needs. An important chapter on safety addresses facts and myths about the use of plastics and elastomers—including the issue of leaching—and how to ensure regulatory compliance. Helping readers understand their choices, the book describes the equipment and systems available to prepare the starting materials for the manufacturing of biological drugs—from disposable containers to filters. The author also discusses costs, regulations, and concerns about waste disposal, and shares his predictions for the future of the disposable bioprocessing industry. A practical manual for those interested in the transition to disposable systems, this book will also interest students of bioprocessing. It offers a timely view of disposable bioprocessing technology as a "game changer" that will facilitate developing new drugs and conducting research in the emerging field of stem cells and gene therapy.

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2011 (4)