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Des environnements à risques

ISBN: 9782911256660 9782356711885 Year: Language: French
Publisher: Presses des Mines
Added to DOAB on : 2017-10-09 10:55:56
License: OpenEdition licence for Books

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Les installations industrielles peuvent-elles provoquer des cancers ? C’est en tout cas la perception de certains acteurs locaux : ils signalent aux autorités publiques que leur environnement recèle des risques pour la santé. Les épidémiologistes ont tendance à récuser les hypothèses relatives à une origine environnementale de ces pathologies, surtout lorsque l’on en fait la cause unique, et ils assurent que ces craintes ne sont pas fondées. Pour faire reconnaître l’existence de risques et en...

Targeting Tumor Perfusion and Oxygenation Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies (Book chapter)

Authors: ---
ISBN: 9789533077031 Year: DOI: 10.5772/23332 Language: English
Publisher: IntechOpen Grant: FP7 Ideas: European Research Council - 243188
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:47:59

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Hypoxia, a partial pressure of oxygen (pO2) below physiological needs, is a limiting factor affecting the efficiency of radiotherapy. Indeed, the reaction of reactive oxygen species (ROS, produced by water radiolysis) with DNA is readily reversible unless oxygen stabilizes the DNA lesion. While normal tissue oxygenation is around 40 mm Hg, both rodent and human tumors possess regions of tissue oxygenation below 10 mm Hg, at which tumor cells become increasingly resistant to radiation damage (radiobiological hypoxia) (Gray, 1953). Because of this so-called “oxygen enhancement effect”, the radiation dose required to achieve the same biologic effect is about three times higher in the absence of oxygen than in the presence of normal levels of oxygen (Gray et al., 1953; Horsman & van der Kogel, 2009). Hypoxic tumor cells, which are therefore more resistant to radiotherapy than well oxygenated ones, remain clonogenic and contribute to the therapeutic outcome of fractionated radiotherapy (Rojas et al., 1992).

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