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This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.

regional absorption --- intestinal permeability --- in situ single-pass perfusion --- fimasartan --- controlled release formulations --- in vitro systems --- colon delivery --- colon microbiota --- gastrointestinal absorption --- dexketoprofen --- gastrointestinal simulator --- microscopy imaging --- liquid–liquid phase separation --- oral absorption --- in vitro dissolution --- intestinal permeability --- regional drug absorption --- Ussing chamber --- biorelevant media --- P-gp --- CYP3A4 --- magnetic resonance imaging --- MRI --- large intestine --- gut --- large bowel --- volume --- transit --- motility --- flow --- lipid-based formulations --- lipolysis --- absorption --- poorly water-soluble drugs --- model --- beads --- gellan gum --- ionotropic gelation --- laponite --- modeling study --- swelling --- gastrointestinal drug release --- polymer/clay composite --- anti-inflammatory --- butyric acid --- curcumin --- modulation --- in vivo --- fluconazole --- biowaiver --- dissolution --- Biopharmaceutics Classification System (BCS) --- bioequivalence --- GastroPlus™ --- in vitro–in vivo correlation (IVIVC) --- diltiazem --- mathematical modeling --- metabolites --- dissolution --- intestinal permeability --- intestinal drug absorption --- experimental and computational permeability methods