Search results: Found 12

Listing 1 - 10 of 12 << page
of 2
>>
Sort by
Novel Approaches for the Delivery of Anti-HIV Drugs

Author:
ISBN: 9783039219001 / 9783039219018 Year: Pages: 208 DOI: 10.3390/books978-3-03921-901-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General)
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.

Keywords

Anti-HIV Drugs --- HIV --- AIDS

The Future of Catholic Theological Ethics

Author:
ISBN: 9783038427711 9783038427728 Year: Pages: 94 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences
Added to DOAB on : 2018-03-26 15:53:35
License:

Loading...
Export citation

Choose an application

Abstract

'The Future of Catholic Theological Ethics' undertakes a search for new ways of making Catholic theological ethics relevant. It engages with a ground-breaking publication 'Reframing Catholic Theological Ethics' (Oxford University Press, 2016) by Joseph Selling, Emeritus Professor of Moral Theology, Catholic University Leuven. Selling opens the volume with a summary of the approach he developed in the above work. The papers presented here cover several major themes that, traditionally, Catholic theological ethics have considered but, according to the authors of the papers, need revisiting. Amongst these themes are: conscience, virtue, natural law, authority, ecumenism, the human person and the theology of theological ethics. The writers represent a variety of approaches, geographical locations and while most of them are Roman Catholic, there is an imbedded ecumenism and interreligious and inter-cultural slant in several discussions. The authors agree that Catholic theological ethics, in order to be relevant, it needs to become more context-sensitive, ecumenical, practice-based, experience-oriented, continuously discerning, pedagogically wide-ranging and theologically articulate. It must be unceasingly willing to review and renew its method as well as revisit its key concepts. It must neither dismiss its long tradition nor stick to its single interpretation.

Micro- and Nanofluidics for Bionanoparticle Analysis

Authors: ---
ISBN: 9783039215942 9783039215959 Year: Pages: 138 DOI: 10.3390/books978-3-03921-595-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

Bionanoparticles such as microorganisms and exosomes are recoganized as important targets for clinical applications, food safety, and environmental monitoring. Other nanoscale biological particles, includeing liposomes, micelles, and functionalized polymeric particles are widely used in nanomedicines. The recent deveopment of microfluidic and nanofluidic technologies has enabled the separation and anslysis of these species in a lab-on-a-chip platform, while there are still many challenges to address before these analytical tools can be adopted in practice. For example, the complex matrices within which these species reside in create a high background for their detection. Their small dimension and often low concentration demand creative strategies to amplify the sensing signal and enhance the detection speed. This Special Issue aims to recruit recent discoveries and developments of micro- and nanofluidic strategies for the processing and analysis of biological nanoparticles. The collection of papers will hopefully bring out more innovative ideas and fundamental insights to overcome the hurdles faced in the separation and detection of bionanoparticles.

Fungal Infections in Immunocompromised Hosts

Authors: ---
ISBN: 9783038977162 Year: Pages: 212 DOI: 10.3390/books978-3-03897-717-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Microbiology --- Biology --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
License:

Loading...
Export citation

Choose an application

Abstract

This book is a printed edition of the Special Issue Fungal Infections in Immunocompromised Hosts that was published in JoF

Keywords

Candida auris --- Aspergillus fumigatus --- antifungal resistance --- multidrug resistance --- mechanisms of antifungal resistance --- liver disease --- hepatic impairment --- invasive fungal infection --- antifungal agent --- antifungal drug --- toxicity --- Immunotherapy --- invasive aspergillosis --- Aspergillus fumigatus --- fungal infections --- innate immunity --- adaptive immunity --- cell therapy --- cytokine therapy --- taxonomy --- fungal nomenclature --- phylogenetics --- species complex --- invasive fungal infections --- mycoses --- immune reconstitution inflammatory syndrome --- fungal immunity --- prognostic risk model --- prediction models --- risk score --- invasive mold disease --- hematological malignancy --- risk assessment --- antifungal stewardship --- paracoccidioidomycosis --- HIV --- cancer --- lymphoma --- kidney transplant --- TNF inhibitors --- literature review --- MALDI-ToF MS --- yeast --- fungus --- AIDS --- IRIS --- cat-transmitted sporotrichosis --- immunocompromised hosts --- mycoses of implantation --- sporotrichosis --- Sporothrix brasiliensis --- Sporothrix schenckii --- subcutaneous mycoses --- invasive fungal infection --- non-culture-based diagnostics --- aspergillosis --- candidiasis --- Aspergillus PCR --- galactomannan --- lateral flow --- beta-d-glucan --- T2 Candida --- candidemia --- Candida meningoencephalitis --- (1?3)-?-d-glucan --- T2Candida --- PCR --- liposomal amphotericin B --- micafungin --- anidulafungin --- Aspergillus --- anti-fungal agents --- hematological malignancies

Measures of Spirituality/Religiosity (2018)

Author:
ISBN: 9783038979326 9783038979333 Year: Pages: 180 DOI: 10.3390/books978-3-03897-933-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Religion
Added to DOAB on : 2019-05-09 17:16:14
License:

Loading...
Export citation

Choose an application

Abstract

The interest in the topic of spirituality as a more or less independent dimension of quality of life is continuously growing, and research questions are beginning to change as the field of religiosity changes, becoming more diverse and pluralistic. Addressing new topics in health research also relies on standardized questionnaires. The number of instruments intended to measure specific aspects of spirituality is growing, and it is particularly difficult to evaluate the new instruments. This Special Issue will focus on some of the established instruments (updating them to different languages and cultures), but will also describe the features and intentions of newly-developed instruments, which may potentially be used in larger studies to develop knowledge relevant to spiritual care and practice. This Special Issue will serve as a resource on the instruments used to study the wide range of organized religiosity, the individual experience of the divine, and an open approach in the search for meaning and purpose in life.

Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions

Author:
ISBN: 9783038979920 9783038979937 Year: Pages: 212 DOI: 10.3390/books978-3-03897-993-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
License:

Loading...
Export citation

Choose an application

Abstract

Oral health is general health. If the oral cavity is kept healthy, the whole body is always healthy. Bacteria in the oral cavity do not stay in the oral cavity, but rather they travel throughout the body and can induce various diseases. Periodontal pathogens are involved in tooth loss. The number of remaining teeth decreases with age. People with more residual teeth can bite food well and live longer with lower incidence of dementia. There are many viruses in the oral cavity that also cause various diseases. Bacteria and viruses induce and aggravate inflammation, and therefore should be removed from the oral cavity. In the natural world, there are are many as yet undiscovered antiviral, antibacterial and anti-inflammatory substances. These natural substances, as well as chemically modified derivatives, help our oral health and lead us to more fulfilling, high quality lives. This Special Issue, entitled “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”, was written by specialists from a diverse variety of fields. It serves to provide readers with up-to-date information on incidence rates in each age group, etiology and treatment of stomatitis, and to investigate the application of such treatments as oral care and cosmetic materials.

Keywords

metabolomics --- oral cell --- benzaldehyde --- eugenol --- inflammation --- cytotoxicity --- stomatitis --- recurrent aphthous stomatitis --- oral lichen planus --- CCN2 --- glucocorticoids --- alkaloids --- anti-human immunodeficiency virus (HIV) --- antiviral --- natural product --- human virus --- inflammatory disease --- stomatitis --- periodontitis --- anti-osteoclast activity --- cepharanthin --- herbal medicine --- natural product --- arachidonic acid cascade --- allergic rhinitis --- mice --- quercetin --- thioredoxin --- nasal epithelial cell --- production --- increase --- in vitro --- in vivo --- nutritionally variant streptococci --- antimicrobial susceptibilities --- oral microbiota --- infective endocarditis --- kampo formula --- traditional Japanese herbal medicine --- stomatitis --- mucositis --- Hangeshashinto --- polyphenol --- chromone --- lignin-carbohydrate complex --- alkaline extract --- Kampo medicine --- glucosyltransferase --- angiotensin II blocker --- QSAR analysis --- oral diseases --- dental application --- Chinese herbal remedies --- stomatitis --- periodontitis --- Kampo --- traditional medicine --- Jixueteng --- Juzentaihoto --- technical terms --- gargle --- tongue diagnosis --- mastic --- pathogenic factors --- quantitative structure-activity relationship --- machine learning --- random forest --- natural products --- tumour-specificity --- Kampo medicine --- constituent plant extract --- stomatitis --- oral inflammation --- quantitative structure-activity relationship (QSAR) analysis --- metabolomics

The Interplay of Microbiome and Immune Response in Health and Diseases

Authors: ---
ISBN: 9783039216468 9783039216475 Year: Pages: 206 DOI: 10.3390/books978-3-03921-647-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-12-09 11:49:16
License:

Loading...
Export citation

Choose an application

Abstract

[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]

Keywords

microbiota --- rheumatoid arthritis --- anti-TNF-? --- methotrexate --- etanercept --- disease activity --- microbiome --- health --- precision medicine --- genomics --- bacteriocins --- bacteriophages --- antibiotics --- gastrointestinal diseases --- dysbiosis --- gut barrier --- gut microbiota --- virus --- vaginal microbiota --- HIV --- HPV --- HSV2 --- cytokines --- chemokines --- innate immunity --- adaptive immunity --- microbiota --- autoimmunity --- etiopathogenesis --- Candida albicans --- 2,3-dihydroxy-4-methoxyBenzaldehyde --- melanin --- colitis --- anaerobic bacteria --- aerobic bacteria --- gut microbiota --- gut-liver axis --- chronic liver diseases --- fecal transplantation --- probiotics --- gut microbiota --- immunological niche --- dysbiosis --- cancer --- immune system --- cutaneous immunity --- microbiome --- Staphylococcus spp., T cells --- Staphylococcus aureus --- Staphylococcus epidermis --- commensals --- atopic dermatitis --- intravenous immunoglobulin G --- colitis --- dextran sulfate sodium --- mice --- inflammation --- cytokines --- Candida albicans --- Escherichia coli --- Enterococcus faecalis --- gut microbiota --- chemo free treatment --- lymphoid malignancies --- 16S rRNA gene --- chondroitin sulfate disaccharide --- co-occurrence network --- global network --- microbial interactions --- microbiome --- modularity --- superoxide dismutase --- gut microbiota --- macrophages --- TLR mimicry --- immune epigenetics --- metabolism --- sterile inflammation --- microbiota --- microbiome --- immunotherapy --- adoptive cell transfer (ACT) --- CAR T-cell --- TCR --- TIL --- checkpoint inhibitors --- immuno-oncology --- cancer --- diet --- n/a

Carotenoids

Author:
ISBN: 9783039218646 9783039218653 Year: Pages: 168 DOI: 10.3390/books978-3-03921-865-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-01-07 09:08:26
License:

Loading...
Export citation

Choose an application

Abstract

Carotenoids are a group of natural pigments, consisting of more than 750 compounds. They are mostly yellow, orange, or red in color, due to the system of conjugated double bonds. This structural element is also responsible for the good antioxidant properties of many carotenoids. Carotenoids have shown numerous biological activities (not only as provitamin A), e.g., preventive properties of fruits and vegetables. As lipophilic compounds, their uptake and storage in the body are dependent on various conditions. In vitro and in vivo data showed stimulating and inhibitory effects of matrix compounds on bioaccessibility and bioavailability of carotenoids.

Keywords

?-carotene --- lycopene --- antioxidants --- free radicals --- ageing --- fruit --- vegetables --- ?-carotene --- HIV --- nelfinavir --- interaction --- pharmacokinetics --- carotenoids --- astaxanthin --- oxidative stress --- antioxidant --- chelating compound --- metal ions --- antireductant --- antiradical --- cationic lipid --- carotenoid --- antisense oligonucleotide --- exon skipping --- Duchenne muscular dystrophy --- ?-carotene --- lutein --- chlorophyll --- spent coffee grounds --- soil amendment --- lettuce --- accelerated solvent extraction --- pressurized fluid extraction --- ethanol --- carrots --- ?-carotene --- antioxidants --- marine carotenoids --- inflammation --- oxidative stress --- cardiovascular disease --- flavonoids --- carotenoids --- antioxidant synergism --- antioxidant antagonism --- free radical kinetics --- dye-sensitized solar cells --- carotenoid and chlorophyll derivatives --- singlet-triplet annihilation --- carotenoids --- xanthophylls --- fluorocarotenoids --- chlorocarotenoids --- bromocarotenoids --- iodocarotenoids --- silicon carotenoids --- nitrogen carotenoids --- sulfur carotenoids --- selenium carotenoids --- iron carotenoids --- carotenoids --- xanthophylls --- cancer chemoprevention --- mechanisms --- B16F10 --- ?-carotene --- PC-3 --- SK-Hep-1 --- VEGF --- oxidative stress --- ROS --- RNS --- antioxidants --- carotenoids --- cardiovascular disease --- carotenoids --- hydrophilic --- esterification --- PEG conjugates --- cycloaddition --- carotenoid --- stability --- feed processing --- storage --- carotenoids --- extraction --- solubility --- injection solvent --- liquid chromatography

Refugee, Migrant and Ethnic Minority Health

Authors: --- --- ---
ISBN: 9783039216444 9783039216451 Year: Pages: 526 DOI: 10.3390/books978-3-03921-645-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 11:49:15
License:

Loading...
Export citation

Choose an application

Abstract

International migration, particularly to Europe, has increased in the last few decades, making research on aspects of this phenomenon, including numbers, challenges, and successes, particularly vital. This Special Issue highlights this necessary and relevant area of research. It presents 37 articles including studies on diverse topics relating to the health of refugees and migrants. Most articles (28) present studies focusing on European host countries. The focus on Europe is justified if we take into consideration the increased number of refugees and migrants who have come to Europe in recent years. However, there are also articles which present studies from countries in other continents. The topics discussed in the Issue include healthcare utilization, infectious diseases, mother and child health, mental health, and chronic diseases. Finding from the included articles indicate that further development of guidelines and policies at both local and international levels is needed. Priorities must be set by encouraging and funding in-depth research that aims to evaluate the impact of existing policies and interventions. Such research will help us formulate recommendations for the development of strategies and approaches that improve and strengthen the integration of migrants and refugees into the host countries.

Keywords

breastfeeding --- complementary feeding --- Chinese --- immigrant mothers --- infant --- obesity --- post-traumatic stress disorder (PTSD) --- pain --- pain perception --- understanding of illness --- culture --- family-oriented societies --- refugee and migrant women --- sexual and reproductive health --- training --- knowledge --- confidence --- health care professionals --- emergency care --- triage --- healthcare system strengthening --- migrant health --- North Korean refugees --- depression --- early trauma --- negative automatic thoughts --- path analysis --- ambulance --- economic recession --- emergency medical service --- Greece --- primary healthcare system --- refugee --- triage --- public health --- asylum seeker --- Electronic Health Insurance Card --- refugee --- Germany --- refugee health --- asylum seekers --- migrants --- infectious diseases --- vaccination --- Italy --- refugee and migrant (R&M) health --- refugee crisis --- healthcare --- European Union (EU) --- migrant health --- preparedness --- communicable diseases --- tuberculosis --- LTBI --- refugee --- asylum --- infection --- IGRA --- infectious diseases --- migrant --- asylum seekers --- psychiatric emergency services --- involuntary treatment --- psychiatric hospitalization --- migrants --- sexual health --- help-seeking behavior --- systematic review --- aggression --- emergency department --- workplace violence --- migrants --- failed asylum seekers --- psychiatric emergency services --- psychiatric hospitalisation --- acute stress --- multidimensional intercultural training acculturation model (MITA) --- intercultural competence --- traumatic events --- mental health --- Middle Eastern refugee adolescents --- migration --- health --- infection --- linkage --- care --- sexual and reproductive health --- adolescent --- refugee --- migrant --- young women --- knowledge --- access --- experiences --- systematic review --- Africa --- obesity --- immigration --- education --- inequalities --- health survey --- refugee --- adolescent --- risk factor --- protective factor --- HIV --- AIDS --- stigma --- refugees --- migrants --- economic crisis --- Greece --- migration --- National Health System --- refugee --- Southeast Europe --- immigrant --- healthcare --- HBV --- CHB --- screening --- vaccination --- refugees --- migrants --- pregnancy --- migration --- refugees --- health care provision --- reception center --- sexual violence --- migrants --- refugees --- asylum seekers --- applicants for international protection --- Europe --- prevalence --- hepatitis C --- screening --- migrants --- viral hepatitis elimination --- European Union --- North African --- immigration --- health care --- emergency department --- disparities --- VPD --- immunisation strategies --- health systems --- refugees --- migrants --- cost effectiveness --- healthcare --- migration --- refugee --- asylum seeker --- medical service --- migrant --- medical care --- doctor --- Europe --- Germany --- fruit --- vegetable --- immigrant --- Portuguese --- health --- refugees women --- HIV --- mental health --- stigma --- discrimination --- access to care --- disease prevention --- public health --- stigma --- refugees --- migrants --- MMR vaccination --- measles --- vaccine hesitancy --- autism --- Rinkeby --- Tensta --- immigrants --- Polish --- religiosity --- lifestyle behavior --- smoking --- alcohol consumption --- physical activity --- overweight --- obesity --- migrant populations --- schistosomiasis/schistosoma --- strongyloidiasis/strongyloides --- screening/diagnosis --- treatment --- public health --- GRADE --- refugee --- health --- migration --- chronic disease --- infectious disease --- n/a

The Impact of Caffeine and Coffee on Human Health

Authors: ---
ISBN: 9783039218349 9783039218356 Year: Pages: 322 DOI: 10.3390/books978-3-03921-835-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:21:22
License:

Loading...
Export citation

Choose an application

Abstract

The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.

Keywords

accidental death --- caffeine --- caffeine intoxication --- intoxication --- Suicide --- HIV-HCV co-infection --- liver fibrosis --- coffee --- alcohol consumption --- coffee --- tea --- European Prospective Investigation into Cancer and Nutrition --- 24-h dietary recall --- whole-blood --- mRNA --- transcriptomics --- gene expression --- coffee --- the Norwegian Women and Cancer Cohort (NOWAC) --- caffeine --- myocardial perfusion --- coronary artery disease --- adenosine --- regadenoson --- dipyridamole --- caffeine intake --- assisted reproduction techniques --- risk factors --- implantation --- clinical pregnancy --- live birth --- epidemiology --- bias --- causation --- coffee --- pregnancy --- coffee --- depression --- cohort study --- Mendelian Randomization --- coffee --- caffeine --- behavior --- causality --- genetic epidemiology --- epidemiological methods --- cardiovascular disease --- coffee consumption --- gene-diet interaction --- longevity --- NADH dehydrogenase --- polymorphism --- serum chloride levels --- CYP1A2 --- ADORA2A --- time trial performance --- caffeine metabolism --- pharmacological ergogenic aid --- polymorphism --- anxiety --- ergogenic --- adenosine receptor --- cytochrome P450 --- caffeine --- pharmacogenomics --- coffee --- caffeine --- chlorogenic acids --- phenolic --- cognition --- cognitive --- mood --- age --- sex --- caffeine --- wine --- chocolate --- aging --- cognition --- adult --- coffee --- hearing --- protection --- tinnitus --- Caffeine --- placebo --- sport --- exercise --- health --- expectancy --- cognitions --- caffeine --- coffee --- systematic review --- pregnancy --- safety --- individual responses --- ergogenic aid --- supplement --- did not respond --- responders --- n/a --- caffeine --- coffee --- tea --- soda --- energy drinks --- mate --- guidelines --- country --- consumption --- population --- public policy --- coffee --- caffeine --- lipids --- biomarkers --- trial --- lysophosphatidylcholine --- lipidomics --- n/a

Listing 1 - 10 of 12 << page
of 2
>>
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (12)


License

CC by-nc-nd (12)


Language

english (10)

eng (2)


Year
From To Submit

2020 (3)

2019 (8)

2018 (1)