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Enzymes and Their Biotechnological Applications

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ISBN: 9783038421481 9783038421474 Year: Pages: 468 DOI: 10.3390/books978-3-03842-147-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 12:11:22
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Thermophiles and Thermozymes

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ISBN: 9783038978169 9783038978176 Year: Pages: 198 DOI: 10.3390/books978-3-03897-817-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-04-25 16:37:17
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Interest in the study of life in hot environments, both with respect to the inhabiting microorganisms and the enzymes they produce, is currently very high. The biological mechanisms responsible for the resistance to high temperatures are not yet fully understood, whereas thermostability is a highly required feature for industrial applications. In this e-book, the invited authors provide diverse evidence contributing to the understanding of such mechanisms and the unlocking of the biotechnological potential of thermophiles and thermozymes.

Enzyme-Mediated Stereoselective Synthesis

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ISBN: 9783039219360 9783039219377 Year: Pages: 116 DOI: 10.3390/books978-3-03921-937-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Inorganic Chemistry
Added to DOAB on : 2020-01-07 09:08:26
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This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines.

Synthetic DNA and RNA Programming

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ISBN: 9783039217342 9783039217359 Year: Pages: 188 DOI: 10.3390/books978-3-03921-735-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease.

Keywords

fluorescent reporter --- live cell imaging --- microRNA quantification --- optogenetics --- small molecule drug screening --- Escherichia coli --- recombinant protein production --- gene overexpression --- growth effect --- ASKA collection --- codon bias --- branched-chain amino acids --- gene ontology --- genetic code expansion --- protein kinase B --- phosphoinositide dependent kinase 1 --- phosphoseryl-tRNA synthetase --- tRNASep --- alanyl-tRNA synthetase --- class II aminoacyl-tRNA synthetase --- expanded genetic code --- lysine acetylation --- posttranslational modification --- genetic code expansion --- transfer RNA --- synthetic biology --- non-canonical amino acids --- selenocysteine --- genetic code expansion --- release factor 1 --- amber stop codon suppression --- M. jannaschii orthogonal pair --- fluorescence-based screen --- cyclic peptides --- biopharmaceuticals --- mRNA display --- yeast two hybrid --- tRNASer --- mistranslation --- anticodon --- functional conservation --- alternative amino acid and nucleotide repertoires --- alternative core cellular chemistries --- biocontainment --- genetic firewall --- genetic isolation --- orthogonal central dogma of molecular biology --- synthetic life --- xenobiology --- genome engineering --- synthetic biology --- yeasts --- Metschnikowia --- genetic tools --- DNA delivery --- CUG-Ser --- reverse polymerization --- tRNA editing --- tRNA repair --- protein engineering --- synthetic biology --- tRNA --- misacylation --- indirect tRNA aminoacylation --- AspRS --- GluRS-like --- genetic code expansion --- genome synthesis --- genome editing --- microRNA --- protein modification --- RNA metabolism --- tRNA --- synthetic biology --- unnatural amino acids --- unnatural nucleotides

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english (4)


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2019 (3)

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