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Additive Manufacturing Technologies and Applications

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ISBN: 9783038425489 9783038425496 Year: Pages: VI, 182 DOI: 10.3390/books978-3-03842-549-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2017-12-27 09:05:09
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The present Special Issue proposes articles in the area of Additive Manufacturing with particular attention to the different employed technologies and the several possible applications. The main investigated technologies are the Selective Laser Sintering (SLS) and the Fused Deposition Modelling (FDM). These methodologies, combined with the Computer Aided Design (CAD), provide important advantages. Numerical, analytical and experimental knowledge and models are proposed to exploit the potential advantages given by 3D printing for the production of modern systems and structures in aerospace, mechanical, civil and biomedical engineering fields. The 11 selected papers propose different additive manufacturing methodologies and related applications and studies.

Drug Delivery Technology Development in Canada

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ISBN: 9783039280049 9783039280056 Year: Pages: 352 DOI: 10.3390/books978-3-03928-005-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-01-07 09:21:22
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Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community.

Keywords

doxorubicin --- MG63 --- Vitamin D --- DOX-Vit D --- hypoxia-induced chemoresistance --- cisplatin --- polymeric micelle --- EGFR-targeted therapy --- STAT3 --- HIF-1 --- GE11 peptide --- pharmacological Inhibitors of HIF-1 and STAT3 --- combination therapy --- pharmacokinetics --- antibodies --- radiolabeling --- biodistribution --- mouse models --- oral formulation --- amphotericin B --- fungal infections --- parasitic infections --- developing world --- drug delivery --- liposomes --- drug delivery systems --- innovation --- lipid nanoparticles --- Metaplex --- triggered drug release --- liposomes --- ultrasound --- magnetic fields --- radiation --- oral delivery --- biological barriers --- co-delivery --- throughput --- sustained delivery --- phospholipid complex --- rosmarinic acid --- bioaccessibility --- dissolution --- TNO gastrointestinal model --- gastrointestinal simulator --- phytosterols --- tocopherols --- liposomes --- canola oil deodorizer distillate --- model orange juice --- virus --- plant --- bacteriophage --- phage display --- drug discovery --- encapsulation --- drug delivery --- blood-brain barrier --- intra-arterial chemotherapy --- malignant gliomas --- primary central nervous system lymphomas --- transdermal drug delivery --- Canada --- skin --- permeation enhancers --- oral, head and neck squamous cell carcinoma --- targeted therapies --- drug delivery systems --- nanoparticles --- controlled drug delivery --- circadian clock --- chronotherapy --- precision medicine --- cationic gemini surfactant --- melphalan --- inclusion complex --- ROESY NMR spectroscopy --- 3D spheroid --- drug-resistant melanoma --- liposome --- water miscible solvents --- remote loading --- staurosporine --- cancer --- gambogic acid --- loading gradients --- mefloquine --- child friendly formulation --- blood-brain barrier (BBB) --- drug delivery --- transient modulation --- HAV6 cadherin peptide --- adenanthin --- magnetic resonance imaging (MRI) --- medulloblastoma --- drug delivery --- pharmaceutics --- drug development --- formulation and dosage form development --- translational research --- biologicals --- small molecules --- clinical trials --- pharmacokinetics --- medical devices --- route of administration --- nifedipine --- emulsion --- flavonoids --- topical formulation --- quercetin --- photostabilizers

Remote Sensing based Building Extraction

Authors: --- --- ---
ISBN: 9783039283828 9783039283835 Year: Pages: 442 DOI: 10.3390/books978-3-03928-383-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Construction
Added to DOAB on : 2020-04-07 23:07:09
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Building extraction from remote sensing data plays an important role in urban planning, disaster management, navigation, updating geographic databases, and several other geospatial applications. Even though significant research has been carried out for more than two decades, the success of automatic building extraction and modeling is still largely impeded by scene complexity, incomplete cue extraction, and sensor dependency of data. Most recently, deep neural networks (DNN) have been widely applied for high classification accuracy in various areas including land-cover and land-use classification. Therefore, intelligent and innovative algorithms are needed for the success of automatic building extraction and modeling. This Special Issue focuses on newly developed methods for classification and feature extraction from remote sensing data for automatic building extraction and 3D

Keywords

roof segmentation --- outline extraction --- convolutional neural network --- boundary regulated network --- very high resolution imagery --- building boundary extraction --- convolutional neural network --- active contour model --- high resolution optical images --- LiDAR --- richer convolution features --- building edges detection --- high spatial resolution remote sensing imagery --- building --- modelling --- reconstruction --- change detection --- LiDAR --- point cloud --- 3-D --- building extraction --- deep learning --- attention mechanism --- very high resolution --- imagery --- building detection --- aerial images --- feature-level-fusion --- straight-line segment matching --- occlusion --- building regularization technique --- point clouds --- boundary extraction --- regularization --- building reconstruction --- digital building height --- 3D urban expansion --- land-use --- DTM extraction --- open data --- developing city --- accuracy analysis --- building detection --- building index --- feature extraction --- mathematical morphology --- morphological attribute filter --- morphological profile --- building extraction --- deep learning --- semantic segmentation --- data fusion --- high-resolution satellite images --- GIS data --- high-resolution aerial images --- deep learning --- generative adversarial network --- semantic segmentation --- Inria aerial image labeling dataset --- Massachusetts buildings dataset --- building extraction --- simple linear iterative clustering (SLIC) --- multiscale Siamese convolutional networks (MSCNs) --- binary decision network --- unmanned aerial vehicle (UAV) --- image fusion --- high spatial resolution remotely sensed imagery --- object recognition --- deep learning --- method comparison --- LiDAR point cloud --- building extraction --- elevation map --- Gabor filter --- feature fusion --- semantic segmentation --- urban building extraction --- deep convolutional neural network --- VHR remote sensing imagery --- U-Net --- remote sensing --- deep learning --- building extraction --- web-net --- ultra-hierarchical sampling --- 3D reconstruction --- indoor modelling --- mobile laser scanning --- point clouds --- 5G signal simulation --- building extraction --- high-resolution aerial imagery --- fully convolutional network --- semantic segmentation --- n/a

Biofuel and Bioenergy Technology

Authors: --- ---
ISBN: 9783038975960 Year: Pages: 425 DOI: 10.3390/books978-3-03897-597-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-03-21 14:08:22
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The subject of this book is ""Biofuel and Bioenergy Technology"". It aims to publish high-quality review and research papers, addressing recent advances in biofuel and bioenergy. State-of-the-art studies of advanced techniques of biorefinery for biofuel production are also included. Research involving experimental studies, recent developments, and novel and emerging technologies in this field are covered. This book contains twenty-seven technical papers which cover diversified biofuel and bioenergy technology-related research that have shown critical results and contributed significant findings to the fields of biomass processing, pyrolysis, bio-oil and its emulsification; transesterification and biodiesel, gasification and syngas, fermentation and biogas/methane, bioethanol and alcohol-based fuels, solid fuel and biochar, and microbial fuel cell and power generation development. The published contents relate to the most important techniques and analyses applied in the biofuel and bioenergy technology.

Keywords

air-steam gasification --- equilibrium model --- tar --- energy exchange --- exergy efficiency --- bio-electro-Fenton microbial fuel cells (Bio-E-Fenton MFCs) --- wastewater --- photo catalyst --- degradation --- calcination --- chemical oxygen demand (COD) --- MFC --- hydrodynamic boundary layer --- recirculation mode --- shear rate --- voltage --- charge transfer resistance --- biodiesel --- direct transesterification --- Rhodotorula glutinis --- single cell oil --- biogas --- tri-reforming process --- syngas --- methane and carbon dioxide conversion --- hydrogen/carbon monoxide ratio --- first-law/second-law efficiency --- biodiesel --- esterification --- liquid lipase --- superabsorbent polymer --- response surface methodology --- waste wood --- torrefaction --- energy yield --- mass yield --- CHO index --- gross calorific value --- Van Krevelen diagram --- anaerobic digestion --- biogas production --- wastewater treatment --- membrane bioreactors --- anaerobic digestion --- methane --- carbon dioxide --- small-scale biogas plants --- developing countries --- SOFC --- validation --- simulation --- exergy --- syngas --- Chlorella --- coal-fired flue-gas --- screening --- biodiesel property --- mixotrophic cultivation --- thermophilic anaerobic digestion --- corn stover --- prairie cord grass --- unbleached paper --- digester performance --- process stability --- synergistic effects --- microbial community --- Methanothermobacter --- biochemical methane potential --- redox potential reduction --- direct interspecies electron transfer --- electroactive biofilm --- Nejayote --- granular activated carbon --- Jerusalem artichoke --- lignocellulose --- acid pretreatment --- nitric acid --- alkali pretreatment --- enzymatic hydrolysis --- ethanol fermentation --- waste biomass --- Vietnam --- solid biofuel --- calorific value --- mechanical durability --- fatty acid methyl ester --- catalyst --- viscosity --- iodine value --- acidity index --- sewage sludge --- pyrolytic oil --- Taguchi method --- thermogravimetric analysis --- synergistic effect --- combined pretreatment --- ball mill --- ethanol organosolv --- herbaceous biomass --- lignin recovery --- Annona muricata --- biodiesel production --- seed oil --- soursop --- two-step process --- response surface methodology --- RSM --- second-generation biodiesel --- stone fruit --- optimisation --- biodiesel testing --- transesterification --- lignocellulosic biomass --- Miscanthus --- mechanical pretreatment --- organosolv pretreatment --- microbial biofuel --- metabolic engineering --- alkanes --- alcohols --- acetone --- electrochemical hydrogenation --- isopropanol --- membrane contamination --- polymer electrolyte membrane --- relative humidity --- diesel --- Carica papaya --- engine performance --- biodiesel --- characterisation --- porosity --- thermophoretic force --- biomass fuel --- non-premixed combustion --- counter-flow structure --- mathematical modeling --- emulsification --- liquefaction --- bio-oils --- co-surfactant --- surfactant --- diesel --- biogas --- Clostridiales --- hydrogen-producing bacteria --- bioreactors --- anaerobic fermentation --- anaerobic digestion --- microbial community composition

Extraintestinal Manifestations of Coeliac Disease

Authors: ---
ISBN: 9783038977988 9783038977995 Year: Pages: 270 DOI: 10.3390/books978-3-03897-799-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-04-25 16:37:17
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Coeliac Disease (CD) affects at least 1% of the population. “Classical” CD refers to gastrointestinal presentations with anaemia and gastrointestinal symptoms. CD can, however, present with extraintestinal manifestations, the commonest of which are dermatitis herpetiformis and neurological presentations (e.g., ataxia, neuropathy, encephalopathy). Recognition and research into the pathophysiology of such manifestations is likely to enhance our understanding of this complex autoimmune disorder.

Keywords

dermatitis herpetiformis --- coeliac disease --- fracture --- bone health --- quality of life --- Gilles de la Tourette syndrome (GTS) --- children and adults --- motor and vocal/phonic tics --- obsessive-compulsive disorder (OCD) --- non-coeliac gluten sensitivity (NCGS) --- gluten-free diet --- one-year adherence --- dermatitis herpetiformis --- coeliac disease --- prevalence --- epidermal transglutaminase --- gluten-free diet --- long-term prognosis --- dermatitis herpetiformis --- coeliac disease --- gluten-free diet --- small bowel --- villous atrophy --- prognosis --- gluten neuropathy --- coeliac disease --- gluten free diet --- quality of life --- male --- extra-intestinal --- gastrointestinal --- celiac disease --- celiac disease --- dermatitis herpetiformis --- urticaria --- atopic dermatitis --- psoriasis --- recurrent aphtous ulceration --- rosacea --- alopecia areata --- cutaneous vasculitis --- gluten-free diet --- celiac disease --- glandular autoimmunity --- autoimmune thyroid disease --- type 1 diabetes --- polyglandular autoimmune syndrome --- coeliac disease --- osteoporosis --- fractures --- celiac disease --- non-celiac gluten sensitivity --- psychiatric disorders --- depression --- anxiety disorders --- eating disorders --- ADHD --- autism --- psychosis --- autoimmunity --- celiac hepatitis --- gut–liver axis --- liver immunity --- non-alcoholic fatty liver disease --- tolerance --- intestinal barrier --- celiac disease --- extraintestinal --- recognition --- diagnosis --- clinical presentation --- gluten-free diet --- prognosis --- movement disorders --- coeliac disease --- gluten --- gluten free diet --- celiac disease --- gluten --- gliadin --- autoantibody --- B cell --- T cell --- transglutaminase --- synapsin --- ganglioside --- gluten sensitivity --- gastrointestinal symptoms --- molecular mimicry --- intermolecular help --- biomarker --- autoimmune pancreatitis --- coeliac disease --- pancreatic disorders --- screening --- Gluten ataxia --- antigliadin antibodies --- coeliac disease --- MR spectroscopy --- gluten sensitive enteropathy --- antigliadin antibody titre --- gluten sensitivity --- coeliac disease --- gluten free diet --- migraine --- headache --- fatigue --- energy --- celiac disease --- extra-intestinal manifestations --- gluten --- latent celiac disease --- potential celiac disease --- extra-intestinal manifestations --- mild enteropathy --- early developing celiac disease --- genetic gluten intolerance --- natural history --- celiac trait --- celiac disease --- gluten neuropathy --- gluten ataxia --- prevalence --- incidence --- gluten-free diet

Planning, Development and Management of Sustainable Cities

Authors: ---
ISBN: 9783038979067 9783038979074 Year: Pages: 440 DOI: 10.3390/books978-3-03897-907-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2019-05-09 17:16:14
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The concept of ‘sustainable urban development’ has been pushed to the forefront of policymaking and politics as the world wakes up to the impacts of climate change and the destructive effects of the Anthropocene. Climate change has emerged to be one of the biggest challenges faced by our planet today, threatening both built and natural systems with long-term consequences, which may be irreversible. While there is a vast body of literature on sustainability and sustainable urban development, there is currently limited focus on how to cohesively bring together the vital issues of the planning, development, and management of sustainable cities. Moreover, it has been widely stated that current practices and lifestyles cannot continue if we are to leave a healthy living planet to not only the next generation, but also to the generations beyond. The current global school strikes for climate action (known as Fridays for Future) evidences this. The book advocates the view that the focus needs to rest on ways in which our cities and industries can become green enough to avoid urban ecocide. This book fills a gap in the literature by bringing together issues related to the planning, development, and management of cities and focusing on a triple-bottom-line approach to sustainability.

Keywords

spatial decision support systems --- urban planning --- sustainability indicators --- urban metabolism --- sustainable regional development --- land use governance --- regional stakeholder involvement --- precision farming (PF) --- wood fuel --- technology roadmapping (TRM) --- open innovation (OI) --- Germany --- sustainability assessment --- sustainable urban development --- neighborhood sustainability --- neighborhood sustainability assessment index --- sustainable city --- Ipoh --- Malaysia --- scaling-up strategy --- sustainable development --- local new town --- neoliberal capitalism --- Wujin --- China --- low-energy transport --- carbon --- energy consumption --- sociotechnical transition --- innovation --- cities --- United Kingdom --- sustainability --- tree --- urban forest --- forest values --- urban transport --- sustainable transport --- developing cities --- medium-sized cities --- infrastructure --- transport projects --- sustainability --- knowledge management --- practitioner perceptions --- frames --- framing processes --- low carbon cities --- visioning --- urban resilience --- sustainability --- sustainability literacy --- urban development --- public participation --- urban planning --- civic engagement --- green economy --- built environment sector --- eco-cities --- sustainable urban development --- green innovation --- low carbon economy --- socio-technical transition --- urban fire --- spatio-temporal features --- SDM, humidity --- GDP --- the fire assimilation effect --- fire inertia effect --- fire caution effect --- urban land development --- natural environmental impact --- driving forces-pressure-state-impact-policy and pattern (DPSIP) --- water supply --- demand --- time-series forecasting --- ARIMA --- urban water sustainability --- Istanbul --- ecosystem approach --- urban ecology --- eco-cities --- process-function ecology --- heat island mitigation --- urban forestry --- green infrastructure --- ecological landscape management --- sustainability index --- mixed land-use --- neighbourhood --- travel behaviour --- perception --- indicator --- stakeholder --- megacity --- co-design --- co-production --- bottom-up --- anthropogenic impact --- environmental threshold --- road grades --- heavy-duty vehicles --- emissions --- sustainable transportation --- China --- water asset management --- Gap analysis --- LOS (level of service) --- PIs (performance indicators) --- customer value --- noise pollution --- low-frequency noise --- DEFRA --- human well-being --- sustainability --- power poles --- City Biodiversity Index --- Satoyama Index --- land use mixture --- land cover --- GIS --- sustainability --- sustainable development --- sustainable urban development --- sustainable city --- sustainable urban ecosystems --- sustainability assessment --- smart cities

Hurdles for Phage Therapy (PT) to Become a Reality

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ISBN: 9783039213917 9783039213924 Year: Pages: 484 DOI: 10.3390/books978-3-03921-392-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-12-09 11:49:15
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Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.

Keywords

Staphylococcus aureus --- bacteriophage --- phage therapy --- vB_SauM-fRuSau02 --- Twortlikevirus --- antibiotic --- antimicrobial resistance --- magistral preparation --- compounding pharmacy --- phage therapy --- regulatory framework --- personalized medicine --- bacteriophage --- phage --- horizontal gene transfer --- co-evolution --- phage therapy --- industrial phage application --- antimicrobial resistance (AMR) --- Germany --- pH stability --- phage-host interactions --- genomics --- antibiotic-resistance --- phage preparation --- lysins --- biofilms --- typhoid fever --- Salmonella Typhi --- extended-spectrum beta lactamases (ESBL) --- Democratic Republic of the Congo --- bacteriophages --- MALDI-MS --- Staphylococcus --- bacteriophages --- phage therapy --- Kayvirus --- Viral proteins --- bacteriophage --- therapy --- phage therapy --- bacterial disease --- infection --- target selection --- Bacteriophage --- phage therapy --- resistance --- adaptation --- prophage --- production --- regulation --- phage therapy --- viral genomes --- best practices --- IND --- high-throughput sequencing --- bacteriophages --- phages --- food safety --- foodborne illness --- phage therapy --- history of science --- science communication --- bacteriophage --- phage therapy --- sustainable agriculture --- zoonosis --- antibiotic resistance --- phage therapy --- experimental therapy --- phage cocktails --- anti-phage antibodies --- prophage --- immunomodulation --- phage therapy --- evolution --- bacterial resistance --- virulence --- Listeria ivanovii --- bacteriophages --- alginate --- production --- disinfection --- phagodisinfection --- virus–host interactions --- bacteriophage efficacy --- gastrointestinal tract --- phage therapy --- bacteriophage --- phage therapy --- antimicrobial resistance --- antibiotic --- global health --- developing countries --- infectious disease --- bacteriophage --- phage --- phage therapy --- phage-resistance --- phage therapy --- bacterial infection --- capsule depolymerase --- antibiotic --- animal model --- bacterial resistance --- bacteriophage --- immunology --- innate immunity --- adaptive immunity --- human host --- phage-human host interaction --- bacterial infection --- antibiotic resistance --- bacteriophage --- antibiotic therapy --- phage therapy --- cases report --- abortive infection --- prophage --- adsorption --- Enterococcus --- rhamnopolysaccharide --- bacteriophage --- phage therapy --- Staphylococcus aureus --- biofilm --- antimicrobial --- frequency of resistance --- phage sensitivity --- resistance management --- nontraditional antibacterial --- bacteriophages --- phage therapy --- antibiotic resistance --- Pseudomonas aeruginosa --- Escherichia coli --- Staphylococcus aureus --- Brussels --- Belgium --- phage biocontrol --- patent landscape --- crop production --- bacteriophage --- phage therapy --- multidrug-resistant bacteria --- antimicrobial resistance --- bacteriophage therapy --- compassionate use --- antibiotic resistance --- phage therapy --- PTMP --- ATMP --- regulatory framework --- pharmaceutical paradigm shift --- clinical trial --- magistral formula --- personalized medicine --- phage therapy --- E. faecalis --- OrthoMCL --- antimicrobial resistance --- capsule --- Galleria mellonella --- Klebsiella pneumoniae --- phage therapy --- n/a --- antimicrobial resistance --- bacteriophage --- personalised medicines --- phage therapy --- pharmaceutical legislation --- regulatory framework

Iron as Therapeutic Targets in Human Diseases Volume 1

Authors: --- ---
ISBN: 9783039280827 9783039280834 Year: Pages: 472 DOI: 10.3390/books978-3-03928-083-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2020-04-07 23:07:08
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Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Keywords

cinnamic acid derivatives --- soybean seed ferritin --- iron release --- binding ability --- Fe2+-chelating activity --- reducibility --- adverse event profile --- anaemia --- bioengineering --- labile iron --- intravenous iron --- iron-carbohydrate complex --- iron processing --- iron metabolism --- infection --- innate immunity --- hepcidin --- ferritin --- anemia of inflammation --- pharmaceutical targets --- iron deficiency anemia --- nutrient iron --- oral iron therapy --- FeSO4 --- NaFeEDTA --- non-transferrin-bound iron (NTBI) --- developing countries --- Indonesia --- neurodegeneration --- mitochondria --- therapy --- heme --- haem --- Iron-sulfur --- Friedreich Ataxia --- Oxidative stress --- Iron chelators --- iron deficiency --- anemia --- cancer --- hepcidin --- patient blood management --- malaria --- iron deficiency --- hepcidin --- TNF --- children --- Africa --- Anemia --- iron deficiency --- oral iron salts --- intravenous iron --- Sucrosomial® iron --- M cells --- bioavailability --- tolerability --- efficacy --- iron --- gut microbiota --- iron supplementation --- iron transporters --- mucosal immunity --- SCFA --- intestinal inflammation --- inflammatory bowel disease (IBD) --- colorectal cancer --- oxidative stress --- anaemia --- cardiovascular disease --- chronic kidney disease --- IV iron therapy --- bone homeostasis --- iron overload --- iron deficiency --- osteoclast --- osteoblast --- osteoporosis --- neurodegeneration with brain iron accumulation --- iron chelation therapy --- multifunctional iron chelators --- fluorescent iron chelator --- 3-hydroxy-4-pyridinone --- fluorophore --- rhodamine --- membrane interactions --- bacteria --- antibacterial activity --- histidine --- iron --- anemia --- oxidative stress --- kidney --- chelation --- iron --- retina --- age-related macular degeneration (AMD) --- iron --- lipid --- obesity --- cancer --- neurodegeneration --- iron chelation --- phlebotomy --- NCOA4 --- ferritinophagy --- iron homeostasis --- erythropoiesis --- ferroptosis --- cancer --- Tfr2 --- iron metabolism --- hepcidin --- erythropoiesis --- SNC --- ferritin --- iron mobilization --- chaotropes --- flavin nucleotide --- electron transfer --- kinetics --- ferritin --- iron --- iron delivery --- nanotechnology --- nanocage --- drug delivery --- inflammation --- serum biomarker --- iron metabolism --- hepcidin --- ferroportin --- hemochromatosis --- anemia --- hepcidin --- iron deficiency anemia --- iron dextran --- neonatal period --- pig --- supplementation --- Alzheimer’s disease --- neuroinflammation --- neurodegeneration --- cytokines --- neuroimmune responses --- iron --- genetic hemochromatosis --- non transferrin bound iron --- hepcidin --- ferroportin --- venesections --- Anemia of chronic disease --- anemia of inflammation --- hepcidin --- anti-hepcidin therapy --- iron supplementation --- macrophage --- central nurse macrophage --- red pulp macrophage --- Kupffer cell --- iron metabolism --- erythropoiesis --- erythroblastic islands --- erythrophagocytosis --- inflammation --- iron homeostasis --- lung diseases --- oxygen sensing --- hypoxia --- ferritin --- hereditary hyperferritinemia --- hereditary hypoferritinemia --- iron metabolism --- cataracts syndrome --- neurodegenerative disease --- n/a --- iron --- neurodegeneration --- NBIA --- hepcidin --- iron --- lung --- acute lung injury --- COPD --- lung infection --- cystic fibrosis --- iron --- anaemia --- infection --- malaria --- immunity --- brain development --- growth --- microbiome --- hepcidin --- ferritin --- iron supplementation --- infants --- children --- low and middle income countries --- liver --- iron --- hepcidin --- Mek/Erk --- Hfe --- Bmp/Smad --- iron --- mycobacteria --- immunity --- Alzheimer’s disease --- iron homeostasis --- ferroptosis --- senescence --- chelators --- macrophages --- iron --- metabolism --- inflammation --- iron --- ferritin --- acute kidney injury --- chronic kidney disease --- vascular calcification --- iron --- hepcidin --- ferroportin --- Interleukin-6 --- infection --- rheumatoid arthritis --- iron homeostasis --- iron absorption --- non-haem iron --- flavonoids --- developmental --- iron deficiency anemia --- neonatal --- transferrin receptor --- treatment --- hemochromatosis --- HFE --- natural history --- T lymphocytes --- MHC --- CD8+ T cells --- prevention --- iron homeostasis --- hepcidin --- protein binding --- peritoneal dialysis --- iron --- hepcidin --- iron regulatory proteins --- cardiomyocyte --- chronic heart failure --- pulmonary arterial smooth muscle cells --- pulmonary arterial hypertension --- iron --- brain --- neurophysiology --- cognition --- social behavior --- didox --- iron chelators --- antitumor compound --- iron metabolism --- RRM2 --- SLC40A1 --- ferroportin --- iron overload --- non-HFE --- ferritin --- hemochromatosis --- iron --- chelation --- neurodegenerative diseases --- pituitary --- brain --- hemopexin --- heme homeostasis --- iron homeostasis --- hemolysis --- haptoglobin --- ferroptosis --- inflammation --- biomarker --- heme oxygenase --- liver --- microbiome --- trauma --- hemorrhage --- iron metabolism --- hepcidin --- iron homeostasis --- ferroportin --- n/a

Iron as Therapeutic Targets in Human Diseases Volume 2

Authors: --- ---
ISBN: 9783039281145 9783039281152 Year: Pages: 440 DOI: 10.3390/books978-3-03928-115-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2020-04-07 23:07:08
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Abstract

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Keywords

cinnamic acid derivatives --- soybean seed ferritin --- iron release --- binding ability --- Fe2+-chelating activity --- reducibility --- adverse event profile --- anaemia --- bioengineering --- labile iron --- intravenous iron --- iron-carbohydrate complex --- iron processing --- iron metabolism --- infection --- innate immunity --- hepcidin --- ferritin --- anemia of inflammation --- pharmaceutical targets --- iron deficiency anemia --- nutrient iron --- oral iron therapy --- FeSO4 --- NaFeEDTA --- non-transferrin-bound iron (NTBI) --- developing countries --- Indonesia --- neurodegeneration --- mitochondria --- therapy --- heme --- haem --- Iron-sulfur --- Friedreich Ataxia --- Oxidative stress --- Iron chelators --- iron deficiency --- anemia --- cancer --- hepcidin --- patient blood management --- malaria --- iron deficiency --- hepcidin --- TNF --- children --- Africa --- Anemia --- iron deficiency --- oral iron salts --- intravenous iron --- Sucrosomial® iron --- M cells --- bioavailability --- tolerability --- efficacy --- iron --- gut microbiota --- iron supplementation --- iron transporters --- mucosal immunity --- SCFA --- intestinal inflammation --- inflammatory bowel disease (IBD) --- colorectal cancer --- oxidative stress --- anaemia --- cardiovascular disease --- chronic kidney disease --- IV iron therapy --- bone homeostasis --- iron overload --- iron deficiency --- osteoclast --- osteoblast --- osteoporosis --- neurodegeneration with brain iron accumulation --- iron chelation therapy --- multifunctional iron chelators --- fluorescent iron chelator --- 3-hydroxy-4-pyridinone --- fluorophore --- rhodamine --- membrane interactions --- bacteria --- antibacterial activity --- histidine --- iron --- anemia --- oxidative stress --- kidney --- chelation --- iron --- retina --- age-related macular degeneration (AMD) --- iron --- lipid --- obesity --- cancer --- neurodegeneration --- iron chelation --- phlebotomy --- NCOA4 --- ferritinophagy --- iron homeostasis --- erythropoiesis --- ferroptosis --- cancer --- Tfr2 --- iron metabolism --- hepcidin --- erythropoiesis --- SNC --- ferritin --- iron mobilization --- chaotropes --- flavin nucleotide --- electron transfer --- kinetics --- ferritin --- iron --- iron delivery --- nanotechnology --- nanocage --- drug delivery --- inflammation --- serum biomarker --- iron metabolism --- hepcidin --- ferroportin --- hemochromatosis --- anemia --- hepcidin --- iron deficiency anemia --- iron dextran --- neonatal period --- pig --- supplementation --- Alzheimer’s disease --- neuroinflammation --- neurodegeneration --- cytokines --- neuroimmune responses --- iron --- genetic hemochromatosis --- non transferrin bound iron --- hepcidin --- ferroportin --- venesections --- Anemia of chronic disease --- anemia of inflammation --- hepcidin --- anti-hepcidin therapy --- iron supplementation --- macrophage --- central nurse macrophage --- red pulp macrophage --- Kupffer cell --- iron metabolism --- erythropoiesis --- erythroblastic islands --- erythrophagocytosis --- inflammation --- iron homeostasis --- lung diseases --- oxygen sensing --- hypoxia --- ferritin --- hereditary hyperferritinemia --- hereditary hypoferritinemia --- iron metabolism --- cataracts syndrome --- neurodegenerative disease --- n/a --- iron --- neurodegeneration --- NBIA --- hepcidin --- iron --- lung --- acute lung injury --- COPD --- lung infection --- cystic fibrosis --- iron --- anaemia --- infection --- malaria --- immunity --- brain development --- growth --- microbiome --- hepcidin --- ferritin --- iron supplementation --- infants --- children --- low and middle income countries --- liver --- iron --- hepcidin --- Mek/Erk --- Hfe --- Bmp/Smad --- iron --- mycobacteria --- immunity --- Alzheimer’s disease --- iron homeostasis --- ferroptosis --- senescence --- chelators --- macrophages --- iron --- metabolism --- inflammation --- iron --- ferritin --- acute kidney injury --- chronic kidney disease --- vascular calcification --- iron --- hepcidin --- ferroportin --- Interleukin-6 --- infection --- rheumatoid arthritis --- iron homeostasis --- iron absorption --- non-haem iron --- flavonoids --- developmental --- iron deficiency anemia --- neonatal --- transferrin receptor --- treatment --- hemochromatosis --- HFE --- natural history --- T lymphocytes --- MHC --- CD8+ T cells --- prevention --- iron homeostasis --- hepcidin --- protein binding --- peritoneal dialysis --- iron --- hepcidin --- iron regulatory proteins --- cardiomyocyte --- chronic heart failure --- pulmonary arterial smooth muscle cells --- pulmonary arterial hypertension --- iron --- brain --- neurophysiology --- cognition --- social behavior --- didox --- iron chelators --- antitumor compound --- iron metabolism --- RRM2 --- SLC40A1 --- ferroportin --- iron overload --- non-HFE --- ferritin --- hemochromatosis --- iron --- chelation --- neurodegenerative diseases --- pituitary --- brain --- hemopexin --- heme homeostasis --- iron homeostasis --- hemolysis --- haptoglobin --- ferroptosis --- inflammation --- biomarker --- heme oxygenase --- liver --- microbiome --- trauma --- hemorrhage --- iron metabolism --- hepcidin --- iron homeostasis --- ferroportin --- n/a

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