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iPS Cells for Modelling and Treatment of Human Diseases

ISBN: 9783038421221 9783038421214 Year: Pages: 422 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2016-05-09 15:30:07
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The field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications.

Walkable Neighborhoods: The Link between Public Health, Urban Design, and Transportation

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ISBN: 9783039219308 9783039219315 Year: Pages: 234 DOI: 10.3390/books978-3-03921-931-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Transportation --- Media and communication
Added to DOAB on : 2020-01-30 16:39:46
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It is now widely recognized that individual-based motivational interventions alone are not sufficient to address the global pandemic of physical inactivity (lack of exercise and too much sitting time). There has been a growing interest in the effect the physically built environment can have on people’s active behaviors. The fundamental assumption is that surrounding physical environments can support active behaviors among a large number of people with long-term effects. This topic has received much attention over the last decade, mainly in the three fields of urban design, public health, and transportation. This Special Issue aims to provide multidisciplinary and evidence-based state-of-the-art research on how the locations where people live impact their active behaviors and health outcomes.

Keywords

urban design --- active living --- aging --- physical activity --- sedentary behavior --- age-friendly environments --- older adult --- physical activity --- social connectedness --- physical environment --- citizen science --- Discovery Tool --- built environment --- urban health --- urban form --- walking --- physical activity --- health promotion --- walkability --- neighborhood --- older adult --- chronic diseases --- body mass --- disease mapping --- geographic variation --- obese --- overweight --- spatial analysis --- walkability --- traffic safety --- walking --- cycling --- infrastructure --- active travel --- active transport --- neighbourhood --- scale --- built environment --- physical activity --- walking --- soft mobility --- walkable environment --- physical activity --- health outcomes --- active living --- street network configuration --- peripheral neighbourhoods --- pedestrian flow --- streetscape features --- Istanbul --- walkable neighborhood --- sitting --- elderly --- built environment --- non-communicable diseases --- Africa --- walkable environment --- physical activity --- sedentary behaviour --- neighbourhood --- walkability --- active living --- survey --- questionnaire --- mobility management --- public transport --- step counts --- city planning --- compact city --- neighborhood --- natural experiment --- built environment --- urban design --- policy evaluation --- active living --- liveability --- Australia --- walkability --- environment --- overweight --- obesity --- review

We Are Best Friends: Animals in Society

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ISBN: 9783039215362 9783039215379 Year: Pages: 162 DOI: 10.3390/books978-3-03921-537-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
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Friendships between humans and non-human animals were once dismissed as sentimental anthropomorphism. After decades of research on the emotional and cognitive capacities of animals, we now recognize human–animal friendships as true reciprocal relationships. Friendships with animals have many of the same characteristics as friendships between humans. Both parties enjoy the shared presence that friendship entails along with the pleasures that come with knowing another being. Both friends develop ways of communicating apart from, or in addition to, spoken language. Having an animal as a best friend can take the form of relationship known as the “pet”, but it can also take other forms. People who work with animals often characterize their non-human partners as friends. People who work with search-and-rescue dogs, herding dogs, or police dogs develop and depend on the closeness of friendship. The same holds for equestrians, as horses and riders must understand each other’s bodies and movements intimately. In some situations, animals provide the sole source of affection and interaction in people’s lives. Homeless people who live on the streets with animal companions experience togetherness 24/7. This book explores the various forms these friendships take. It sheds light on what these friendships mean and how they expand the interdisciplinary knowledge of the roles of animals in society.

Aging and Age-related Disorders: From Molecular Mechanisms to Therapies

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ISBN: 9783039213559 9783039213566 Year: Pages: 322 DOI: 10.3390/books978-3-03921-356-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

Early Life Nutrition and Future Health

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ISBN: 9783039282500 9783039282517 Year: Pages: 182 DOI: 10.3390/books978-3-03928-251-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-04-07 23:07:08
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Inequity starts before birth and is programmed in part by nutritional exposures. If these exposures occur around the time of conception, during pregnancy, and/or in infancy or childhood (all critical periods of development) they may alter a child’s health trajectory and impact risk for impaired cognition and learning, and cardiometabolic, immune, and neuropsychiatric diseases and disorders. This Special Issue on “Early Life Nutrition and Future Health” has the following aims: 1) understand the origins of offspring health inequities from an early nutritional perspective; 2) uncover new insights into the environmental, biological, and social mechanisms that underpin these health outcomes in offspring; and 3) present novel targets and approaches to optimise health trajectories and prevent chronic diseases and disorders in later life and across generations. The research projects included herein highlight novel mechanistic, epidemiologic, and intervention studies that target key windows where nutrition has the greatest influence on future health (preconception, prenatal, and postnatal periods) and that explore vulnerable populations and animal models of early life nutritional programming.

Thioredoxin and Glutaredoxin Systems

Authors: ---
ISBN: 9783038978367 9783038978374 Year: Pages: 280 DOI: 10.3390/books978-3-03897-837-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-06-26 08:44:06
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This Special Issue features recent data concerning thioredoxins and glutaredoxins from various biological systems, including bacteria, mammals, and plants. Four of the sixteen articles are review papers that deal with the regulation of development of the effect of hydrogen peroxide and the interactions between oxidants and reductants, the description of methionine sulfoxide reductases, detoxification enzymes that require thioredoxin or glutaredoxin, and the response of plants to cold stress, respectively. This is followed by eleven research articles that focus on a reductant of thioredoxin in bacteria, a thioredoxin reductase, and a variety of plant and bacterial thioredoxins, including the m, f, o, and h isoforms and their targets. Various parameters are studied, including genetic, structural, and physiological properties of these systems. The redox regulation of monodehydroascorbate reductase, aminolevulinic acid dehydratase, and cytosolic isocitrate dehydrogenase could have very important consequences in plant metabolism. Also, the properties of the mitochondrial o-type thioredoxins and their unexpected capacity to bind iron–sulfur center (ISC) structures open new developments concerning the redox mitochondrial function and possibly ISC assembly in mitochondria. The final paper discusses interesting biotechnological applications of thioredoxin for breadmaking.

Keywords

methionine --- methionine sulfoxide --- methionine sulfoxide reductase --- physiological function --- protein --- plant --- repair --- redox homeostasis --- signaling --- stress --- mitochondria --- thioredoxin --- iron–sulfur cluster --- redox regulation --- ALAD --- tetrapyrrole biosynthesis --- redox control --- thioredoxins --- posttranslational modification --- chlorophyll --- redox regulation --- thioredoxin --- ferredoxin-thioredoxin reductase --- chloroplast --- H2O2 --- redox signalling --- development --- regeneration --- adult stem cells --- metazoan --- cyanobacteria --- thioredoxin --- photosynthesis --- redox active site --- thioredoxin --- disulfide --- flavin --- NADPH --- X-ray crystallography --- SAXS --- methanoarchaea --- chilling stress --- cold temperature --- posttranslational modification --- regulation --- ROS --- thiol redox network --- thioredoxin --- thioredoxin --- Calvin-Benson cycle --- photosynthesis --- carbon fixation --- chloroplast --- macromolecular crystallography --- protein-protein recognition --- electrostatic surface --- Chlamydomonas reinhardtii --- thioredoxin --- glutaredoxin --- legume plant --- symbiosis --- redox homeostasis --- stress --- thioredoxin --- monodehydroascorbate reductase --- water stress --- protein oxidation --- antioxidants --- ascorbate --- glutathione --- wheat --- thioredoxin --- thioredoxin reductase --- baking --- redox --- dough rheology --- protein oxidation --- methionine oxidation --- methionine sulfoxide reductases --- oxidized protein repair --- ageing --- Chlamydomonas reinhardtii --- cysteine alkylation --- cysteine reactivity --- MALDI-TOF mass spectrometry --- thioredoxin --- X-ray crystallography --- Isocitrate dehydrogenase --- glutathionylation --- nitrosylation --- glutaredoxin --- Arabidopsis thaliana --- thioredoxins --- plastidial --- specificity --- function --- proteomic --- photosynthesis --- Calvin cycle --- n/a

Human and Animal Sensitivity: How Stock-People and Consumer Perception Can Affect Animal Welfare

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ISBN: 9783039212613 9783039212620 Year: Pages: 234 DOI: 10.3390/books978-3-03921-262-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Animal Sciences
Added to DOAB on : 2019-12-09 11:49:15
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This book presents cross-discipline studies covering aspects ranging from animal science to social/consumer sciences and psychology, with the aim to collect and disseminate information promoting the continuous enhancement of animal welfare by improving stakeholders’ perception of animal welfare. Although animal welfare is about how the animals perceive the surrounding environment, the actual welfare of the animals is dependent on how the stakeholders perceive and weigh animal welfare. The stakeholders can, either directly (i.e., through stock-people interaction with the animals) or indirectly (e.g., when retailers and consumers are willing to pay more for high welfare animal-based products), affect the way animals are kept and handled.

Keywords

veterinary student --- animal ethics --- pain perception --- animal --- animal welfare --- Animal welfare --- husbandry practices --- lambs --- pain --- sheep farmers --- perception --- agreement --- aggression --- animal welfare --- desensitization --- perception --- pigs --- animal welfare --- young adult --- animal attitudes --- children --- farm animals --- animal welfare --- education --- technology --- animal welfare --- Asia --- knowledge --- slaughter --- transport --- training --- animal welfare --- benefit --- profit --- human health --- Asia --- livestock --- farmer perception --- citizen perception --- qualitative research --- free elicitation narrative interviews --- animal welfare --- consumer --- willingness to pay --- pig --- castration --- immunocastration --- information --- survey --- human-animal relationship --- fear --- laying hen --- stockpeople attitudes --- stockperson behaviour --- egg farm --- albumen corticosterone --- welfare --- animal welfare --- stakeholder perception --- text mining --- horse --- donkey --- goat --- sheep --- turkey --- farm animal welfare (FAW) --- willingness to pay --- food safety concerns --- ethical concerns --- perceived consumer effectiveness --- broiler --- dairy buffalo --- human-animal relationship --- animal behavior --- test-retest reliability --- avoidance distance --- milk production --- animal welfare --- animal welfare --- stunning --- religious slaughter --- veterinary students --- Halal meat --- racehorse welfare --- staff shortages --- horse–human relationship --- standards of care --- employee relations --- consumer demand --- economics --- farm animal welfare --- producer perspective

Molecular Research of Endometrial Pathophysiology

Authors: ---
ISBN: 9783039214952 9783039214969 Year: Pages: 378 DOI: 10.3390/books978-3-03921-496-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 16:10:12
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The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.

Keywords

RANK --- endometrium --- endometrial cancer --- prognosis --- immunohistochemistry --- gene expression --- endometriosis --- developmental pathway --- pathogenomics --- mesenchymal stem cells --- endometrial cancer --- mtDNA mutations --- deficit of complex I --- antioxidant response --- mitochondrial biogenesis --- mitochondrial dynamics --- mitophagy --- miRNA --- lncRNAs --- endometrial cancer --- endometriosis --- chronic endometritis --- cell contacts --- tight junction --- adherens junction --- gap junction --- endometrium --- implantation --- decidualization --- endometriosis --- endometrial cancer --- liquid biopsy --- uterine aspirate --- circulating tumour cells (CTCs) --- circulating tumour DNA (ctDNA) --- exosomes --- Vitamin D --- endometrium --- endometrial cancer --- endometrial cancer --- preclinical models --- translational research --- endometrial cancer --- type II endometrial carcinoma --- targeted therapy --- kinase inhibitor --- molecular marker --- protein kinase --- protein phosphatase --- PP2A --- PPP2R1A --- SMAP --- endometriosis --- infertility --- niche --- inflammation --- immunomodulation --- mesenchymal stem cell --- orthoxenograft --- uterine cancer --- avatar --- murine models --- personalized medicine --- targeted therapy --- preclinical studies --- translational research --- endometriosis --- TRP channels --- endometrial stromal cells --- eutopic and ectopic endometrium --- endometrial cell --- pathway --- proliferation --- decidualization --- migration --- angiogenesis --- regeneration --- breakdown --- implantation --- endometrial cancer --- orthotopic xenograft model --- estrogen dependent --- bioluminescence imaging --- contrast-enhanced CT scan --- endometrium --- adult stem cells --- endometrial regeneration --- stem cell markers --- endometriosis --- endometrial cancer --- decidualisation --- oestradiol --- aromatase --- testosterone --- dehydroepiandrosterone (DHEA) --- endometriosis --- endometrial cancer --- sulfatase --- endometriosis --- ectopic stroma --- microRNA --- small RNA sequencing --- EDN1 --- HOXA10 --- miR-139-5p --- miR-375 --- CTCF --- tumour suppressor gene --- haploinsufficiency --- zinc finger --- CRISPR/Cas9 --- cancer --- endometrial cancer --- gene editing --- phosphoinositide 3-kinase --- PIK3CA --- PIK3CB --- p110? --- p110? --- endometrial cancer --- LGR5 --- endometrium --- endometriosis --- menstrual cycle --- macrophages

The Impact of Caffeine and Coffee on Human Health

Authors: ---
ISBN: 9783039218349 9783039218356 Year: Pages: 322 DOI: 10.3390/books978-3-03921-835-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-01-07 09:21:22
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The purpose of this Special Issue is to provide a thorough and up-to-date presentation of research investigating the impact of coffee and/or caffeine intake on various health outcomes. Areas of interest include, but are not limited to, the following topics: Human clinical trials of coffee or caffeine use in relation to disease or intermediate phenotypes. Epidemiological studies of habitual coffee or caffeine intake in relation to human health, among the general public, as well as, among special populations (i.e., children, pregnant women, diabetics, cancer patients, hypertensives, etc.). Mechanisms of action of nutrients and other bioactive components of coffee/caffeine. Studies integrating genetic or physiological markers of coffee/caffeine intake to investigations of coffee and health.

Keywords

accidental death --- caffeine --- caffeine intoxication --- intoxication --- Suicide --- HIV-HCV co-infection --- liver fibrosis --- coffee --- alcohol consumption --- coffee --- tea --- European Prospective Investigation into Cancer and Nutrition --- 24-h dietary recall --- whole-blood --- mRNA --- transcriptomics --- gene expression --- coffee --- the Norwegian Women and Cancer Cohort (NOWAC) --- caffeine --- myocardial perfusion --- coronary artery disease --- adenosine --- regadenoson --- dipyridamole --- caffeine intake --- assisted reproduction techniques --- risk factors --- implantation --- clinical pregnancy --- live birth --- epidemiology --- bias --- causation --- coffee --- pregnancy --- coffee --- depression --- cohort study --- Mendelian Randomization --- coffee --- caffeine --- behavior --- causality --- genetic epidemiology --- epidemiological methods --- cardiovascular disease --- coffee consumption --- gene-diet interaction --- longevity --- NADH dehydrogenase --- polymorphism --- serum chloride levels --- CYP1A2 --- ADORA2A --- time trial performance --- caffeine metabolism --- pharmacological ergogenic aid --- polymorphism --- anxiety --- ergogenic --- adenosine receptor --- cytochrome P450 --- caffeine --- pharmacogenomics --- coffee --- caffeine --- chlorogenic acids --- phenolic --- cognition --- cognitive --- mood --- age --- sex --- caffeine --- wine --- chocolate --- aging --- cognition --- adult --- coffee --- hearing --- protection --- tinnitus --- Caffeine --- placebo --- sport --- exercise --- health --- expectancy --- cognitions --- caffeine --- coffee --- systematic review --- pregnancy --- safety --- individual responses --- ergogenic aid --- supplement --- did not respond --- responders --- n/a --- caffeine --- coffee --- tea --- soda --- energy drinks --- mate --- guidelines --- country --- consumption --- population --- public policy --- coffee --- caffeine --- lipids --- biomarkers --- trial --- lysophosphatidylcholine --- lipidomics --- n/a

Nutrition, Choice and Health-Related Claims

Author:
ISBN: 9783039286485 / 9783039286492 Year: Pages: 362 DOI: 10.3390/books978-3-03928-649-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
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This book presents different articles focused on the role of nutritional properties and/or health-related claims on choice preferences, choice behavior, healthy eating/healthy diet, and the willingness to pay for certain foods.

Keywords

consumer research --- carrier foods --- functional ingredients --- loglinear analysis --- qualified health claim --- older adult --- green tea --- cancer --- purchase intentions --- emotional eating --- food choices --- nutritional claims --- nutrition claims --- health claims --- portion size --- perceptions --- health halo --- food labelling --- consumer --- nudging --- qualitative --- focus groups --- trans-fatty acids --- ultra-processed food products --- food labels --- consumer --- non-communicable disease --- quantile regression --- experimental auction --- lycopene --- information --- consumer --- yoghurt --- label --- a discrete choice-based experiment --- Food Neophobia Scale (FNS) --- food neophobia --- consumer choice --- choice experiment --- allergen --- menu --- packaging --- exposure time --- plant extract --- visual appraisal --- consumer home-test --- nutritional claims --- health claims --- cluster analysis --- food choices --- functional food --- health information --- environmental information --- choice experiment --- sustainability --- consumer preferences --- nutritional labels --- biscuits --- pastries --- Aragón --- nutrition claim --- health claim --- functional food --- WTP --- segmentation --- organic consumer choices --- organic dried strawberries --- nutrient labels --- health attitudes --- consumer heterogeneity --- cross-cultural comparison --- claims --- labeling --- nutrition --- consumer behavior --- policy --- choice architecture --- dining environment --- campus --- college students --- cereal grains --- dietary fiber --- vitamins --- claim --- information --- health claims --- new product development --- nutrition claims --- market success --- food choice --- changes in quality --- changes in prices --- nutrition --- United Kingdom --- Brexit --- consumer research --- willingness to purchase --- non-communicable diseases --- binary logistic regression --- random forest --- food choices --- health consciousness --- red wine --- choice experiment --- clean labels --- alcohol content --- nutritional knowledge --- health --- local --- organic --- greenhouse gas emissions --- consumer --- choice experiment --- willingness to pay --- trade-offs --- n/a

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