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The Epithelial-to-Mesenchymal Transition (EMT) in Cancer

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ISBN: 9783038427933 9783038427940 Year: Pages: VI, 254 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-04-27 16:09:54
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The epithelial-to-mesenchymal transition (EMT) is a highly dynamic process with multiple transitional states, by which epithelial cells can convert into a mesenchymal phenotype. This process involves loss of cellular adhesion and cellular polarity, and an improvement in migratory and invasive properties. It occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing. It is also involved in tumor progression with metastatic expansion, and plays a major role in resistance to cancer treatment. In cancers, EMT inducers are hypoxia, cytokines and growth factors secreted by the tumor microenvironment, stroma crosstalk, metabolic changes, innate and adaptive immune responses, and treatment with antitumor drugs. Switch in gene expression from epithelial to mesenchymal phenotype is triggered by complex regulatory networks involving transcriptional control, non-coding RNAs, chromatin remodeling and epigenetic modifications, alternative splicing, post-translational regulation, protein stability and subcellular localization. Reversion of EMT, the mesenchymal-to-epithelial transition (MET), affects circulating cancer cells when they reach a desirable metastatic niche to develop secondary tumors. More knowledge and control of EMT to MET is necessary and will be beneficial for patients for cancer treatment. This current Special Issue entitled “Epithelial to Mesenchymal Transition in Cancer” will address these questions.

Spin-Crossover Complexes

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ISBN: 9783038428251 9783038428268 Year: Pages: VI, 200 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2018-06-26 14:01:59
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The spin-crossover (SCO) phenomenon originates from the intrinsic bistability of the d-electron configuration, created by the competition between ligand-field splitting and spin-pairing energies in a first coordination sphere of transition metal ions. Since Cambi’s visionary finding of the SCO phenomenon in 1931, considerable knowledge concerning syntheses, crystal structures, magnetic and thermodynamic properties, spectroscopies, molecular orbital calculations, and theories of SCO complexes has accumulated in a very large number of inorganic molecular coordination compounds, and, in addition, inorganic cobaltates and bioinorganic molecular systems. Recent studies which have focused on other electronic properties exhibited by SCO complexes themselves, control of molecular assemblies, and moreover, multifunctionalization of SCO complexes with either different electronic properties or porous frameworks will open the possibility toward future practical applications of SCO complexes. Thus, the fundamentals and applications of SCO complexes afford a very exciting research field in inorganic coordination chemistry and continues to attract growing attention on a wide range of relevant research fields. This Special Issue aims at collecting research and review contributions concerning recent advances in all aspects of SCO and related phenomena and disseminating this extensive knowledge with a broader audience by means of open access publishing. I invite you to contribute papers in the following research areas so that your research can impact the next generation trends in this promising field.

Sustainability Transition Towards a Bio-Based Economy: New Technologies, New Products, New Policies

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ISBN: 9783038973805 9783038973812 Year: Pages: 256 DOI: 10.3390/books978-3-03897-381-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Ecology --- Environmental Sciences
Added to DOAB on : 2018-11-29 10:05:43
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This book proposes an array of 11 key papers aimed at investigating the complex and multifaceted nature of the bio-based economy, focusing both on a conceptual understanding of the transition and on the measurement issues associated with it. More specifically, the papers included in this book can be broadly divided in two groups: (1) those aiming at adding to our understanding of the transition process towards a sustainable bio-based economy; and (2) those aiming at adding to the definition and measurement of the emerging sustainable bio-based economy. The book offers a comprehensive view of the phenomenon, providing a logical framework for understanding the ongoing transition towards a bio-based economy, as well as an overview of existing tools to assess and measure it. Policy-makers will largely benefit from the book, which contributes to taking a further step towards the much-needed transition to sustainability.

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