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Nutrition and Chronic Conditions

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ISBN: 9783038976028 / 9783038976035 Year: Pages: 226 DOI: 10.3390/books978-3-03897-603-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Cardiovascular --- Internal medicine --- Nutrition and Food Sciences
Added to DOAB on : 2019-02-05 10:10:24
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The effects of nutrition in chronic conditions, such as diabetes, cardiovascular disease, dementia, stroke, and inflammatory bowel disease continue to generate interest among researchers. This stems from the fact that diet is a modifiable risk factor for these diseases, which manifest either as single entities or in co-morbid states in individuals and populations around the world. In particular, the prevalence of diabetes and cardiovascular disease is on the rise, especially in developed countries, but also in developing economies, partly due to lifestyle changes, including diet. For example, ischaemic heart disease is the leading cause of death globally. When combined with stroke, these conditions accounted for 15 million deaths in 2015 and are the world’s greatest killers (WHO, 2017). Furthermore, WHO (2016), reported that there were an estimated 422 million adults who were living with diabetes in 2014. This is significantly higher than the 108 million in 1980, representing a rise in worldwide diabetes prevalence from 4.7% in 1980 to 8.5% in 2014 among the adult population.These chronic conditions and their associated complications have significant implications for morbidity and mortality, and incur huge costs to the health services around the world. The composition of the diet, the proportion and types of macronutrients and micronutrients present in the diet are major contributors to these diseases. In addition, the beneficial effects of nutritional interventions have been well documented although differences remain among researchers with respect to their overall impact. The evaluation of the role of nutrition in chronic conditions draws on its effect on body weight and body composition, glycaemic and insulin excursions, vascular remodeling, and gastro-intestinal dysfunction.Therefore, this Special Issue on “Nutrition and Chronic Conditions” aims to evaluate the effect of nutrition in the development, care, and management of chronic conditions. The primary conditions of interest are diabetes, cardiovascular disease, dementia, stroke, and inflammatory bowel disease.

Thinking About Dementia

Authors: ---
Book Series: Studies in Medical Anthropology ISBN: 9780813538020 Year: Language: English
Publisher: Rutgers University Press Grant: Knowledge Unlatched - 101109
Added to DOAB on : 2018-01-25 11:01:47
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Bringing together essays by nineteen respected scholars, this volume approaches dementia from a variety of angles, exploring its historical, psychological, and philosophical implications. The authors employ a cross-cultural perspective that is based on ethnographic fieldwork and focuses on questions of age, mind, voice, self, loss, temporality, memory, and affect.Taken together, the essays make four important and interrelated contributions to our understanding of the mental status of the elderly. First, cross-cultural data show that the aging process, while biologically influenced, is also culturally constructed. Second, ethnographic reports raise questions about the diagnostic criteria used for defining the elderly as demented. Third, case studies show how a diagnosis affects a patient's treatment in both clinical and familial settings. Finally, the collection highlights the gap that separates current biological understandings of aging from its cultural meanings.

Keywords

Anthropology --- dementia --- age --- anthropology --- health --- medicine

Diagnosis of Dementia and Cognitive Impairment

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ISBN: 9783039218844 / 9783039218851 Year: Pages: 140 DOI: 10.3390/books978-3-03921-885-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-01-07 09:08:26
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In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.

Im Leben bleiben

Authors: --- ---
Book Series: Gesellschaft der Unterschiede ISBN: 9783837629965 9783839429969 Year: DOI: 10.14361/9783839429969 Language: German
Publisher: transcript Verlag Grant: Knowledge Unlatched - 103343
Subject: Political Science
Added to DOAB on : 2018-03-30 11:01:58
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Wir werden immer älter. Gleichzeitig gibt es zunehmend Menschen, die mit Demenz altern und nur noch versorgt werden. Klar ist: Wir brauchen Alternativen zu den eingefahrenen Umgangsweisen. Was tun wir, um Orte zu schaffen, an denen wir Leben bleiben können - statt nur Leben? Wie können wir das Lebensumfeld von Menschen mit und ohne Demenz zu "menschenwärmenden Orten" machen? In Deutschland sind zahlreiche Initiativen im Aufbruch: Engagierte Menschen aus Politik, Kultur und Kirche sind auf kreative Weise unterwegs zu Demenzfreundlichen Kommunen. Die drei Autor/innen, eng vertraut mit dem Thema, zeigen Suchbewegungen, Stolpersteine und erste Lösungsansätze auf.

Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping

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ISBN: 9783039216109 / 9783039216116 Year: Pages: 94 DOI: 10.3390/books978-3-03921-611-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:16
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The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain. Correctly classifying the pathogenicity of genomic variants from amongst the large number of variants identified by next-generation sequencing is recognized as perhaps the major challenge facing the field. Deep phenotyping (e.g., imaging, movement analysis) techniques can aid variant interpretation by correctly classifying individuals as affected or unaffected for segregation studies. The lack of information on the clinical phenotype of novel genetic subtypes of neurological disease creates limitations for genetic counselling. Both deep phenotyping and qualitative studies can capture the clinical and patient’s perspective on a disease and provide valuable information. This Special Issue aims to highlight how next-generation sequencing techniques have revolutionised our understanding of the aetiology of brain disease and describe the contribution of deep phenotyping studies to a variant interpretation and understanding of natural history.

Social Safety and Security

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ISBN: 9783039281466 / 9783039281473 Year: Pages: 112 DOI: 10.3390/books978-3-03928-147-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Law
Added to DOAB on : 2020-01-30 16:39:46
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Social safety in social environments entails the sense of feeling safe with other people. Thus, social safety and security are very important to our life. Although research in this area has made significant progress in the past few years, there are still many social problems that require attention and further development in order to secure peace of mind. There is a very clear and accurate understanding and judgment of the overall situation of social security in the current and future period. This Special Issue focuses on a number of contemporary issues in social safety and security. The objective of this book is to rapidly disseminate the latest research and knowledge in this important area.

Wine and Vine Components and Health

Authors: ---
ISBN: 9783039211388 / 9783039211395 Year: Pages: 154 DOI: 10.3390/books978-3-03921-139-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-08-28 11:21:27
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While there is a tremendous literature on the topic of wine and health ranging back to the days of Hippocrates, it is considered that there is an unlimited variety of wine, allowing for the association of senses, nutrition, and hedonism. The history of vine and wine has lasted for at least 7000 years. Vitis represent adaptable plants, and thanks to the large variety of strains, wine is an alchemical mix with unique properties, a rich and original composition in terms of polyphenols, and well known antioxidants. This explains why wine and health are closely linked to nutrition.

Molecular Mechanism of Alzheimer's Disease

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ISBN: 9783039214075 / 9783039214082 Year: Pages: 228 DOI: 10.3390/books978-3-03921-408-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Keywords

?-secretase --- amyloid beta --- calcium signaling --- drug target discovery --- endoplasmic reticulum --- inositol 1,4,5-trisphosphate receptor --- ion channel --- oxidative stress --- ryanodine receptor --- therapy --- amyloid-? oligomer --- protein aggregation --- A?O receptors --- Alzheimer’s disease --- neurodegeneration --- amyloid ? --- Alzheimer’s disease --- cognitive function --- dairy products --- dementia --- inflammation --- microglia --- Alzheimer’s disease --- yeast --- Tau --- amyloid ? --- ubiquitin --- aggregation --- oligomerization --- prion --- CDK5R1 --- lncRNAs --- Alzheimer’s disease --- miR-15/107 --- NEAT1 --- HOTAIR --- MALAT1 --- heat shock response --- heat shock protein --- Alzheimer’s disease --- beta amyloid --- yeast --- Alzheimer’s disease --- complement receptor 1 --- CR1 length polymorphism --- CR1 density --- complement C3b/C4b receptor --- complement --- dementia --- molecular biology --- neurosciences --- genetic risk --- Alzheimer’s disease --- brain glucose metabolism --- neuronal differentiation --- neuronal degeneration --- Prolyl isomerases --- Pin1 --- type 2 diabetes --- type 3 diabetes --- miR-34c --- dendritic spine --- Alzheimer’s disease --- Alzheimer’s disease --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- Alzheimer’s disease --- cystathionine-?-lyase CTH gene --- DNA methylation --- epigenetics --- epigenome-wide association study --- methylome --- methylenetetrahydrofolate reductase MTHFR gene --- nutrition --- S-adenosylmethionine --- vitamin B complex --- Alzheimer’s disease --- sleep disturbance --- sleep fragmentation --- slow-wave sleep --- amyloid beta --- tau --- proteostasis --- default-mode network --- cognitive behavioral therapy for insomnia --- APOE gene --- apolipoprotein E --- DNA methylation --- mild cognitive impairment --- Hispanics

Health Benefits of Mediterranean Diet

Authors: ---
ISBN: 9783039214938 / 9783039214945 Year: Pages: 274 DOI: 10.3390/books978-3-03921-494-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2019-12-09 11:49:15
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Growing evidence shows that a dietary pattern inspired by Mediterranean dietprinciples is associated with numerous health benefits. A Mediterranean-typediet has been demonstrated to exert a preventive effect toward cardiovasculardiseases, in both Mediterranean and non-Mediterranean populations. Part ofthese properties may depend on a positive action toward healthier metabolism,decreasing the risk of diabetes and metabolic-syndrome-related conditions.Some studies also suggested a potential role in preventing certain cancers. Finally,newer research has showed that a higher adherence to the Mediterranean diet isassociated with a lower risk of cognitive decline, depression, and other mentaldisorders. Overall, a better understanding of the key elements of this dietarypattern, the underlying mechanisms, and targets, are needed to corroboratecurrent evidence and provide insights on new and potential outcomes.ThisSpecial Issue welcomes original research and reviews of literature concerningthe Mediterranean diet and various health outcomes:Observational studies onestablished nutritional cohorts (preferred), case-control studies, or populationsample on the association with non-communicable diseases;Level of evidenceon the association with human health, including systematic reviews and metaanalyses;Evaluation of application of Mediterranean diet principles in non-Mediterranean countries;Description of mechanisms of action, pathways, andtargets at the molecular level, including interaction with gut microbiota.

Keywords

Mediterranean diet --- dietary intervention --- diet --- nutrition --- translation --- non-alcoholic fatty liver disease --- cardiovascular disease --- Mediterranean diet --- physical activity --- self-concept --- socioeconomic factors --- Mediterranean diet --- diabetes --- cardiovascular risk --- glucose control --- plasma lipids --- relative Mediterranean diet score --- Mediterranean diet --- questionnaire --- children --- adolescents --- obesity --- Mediterranean diet --- athletes --- Spain --- dietary intake --- catechins --- resveratrol --- olive oil --- wine --- BMI --- Mediterranean diet --- barriers --- dietary change --- childbearing age --- diet quality --- depressive symptoms --- risk factors --- epidemiology --- immune system --- prevention --- hypothalamic–pituitary–adrenal-HPA axis --- Mediterranean diet --- motivational climate --- sports --- university students --- Mediterranean diet --- metabolomics --- microbiome --- Mediterranean diet --- DNA damage --- DNA repair --- telomere length --- dietary intervention study --- Mediterranean diet --- sleep quality --- cognitive decline --- dementia --- weight status --- mental health --- obesity --- cohort --- Italy --- Mediterranean diet --- quality of life --- mental health --- fruit --- vegetable --- dairy --- nuts --- fish --- whole-grain --- food groups --- Mediterranean diet --- pregnancy --- offspring --- child health --- Mediterranean diet --- Mediterranean diet pyramid --- noncommunicable diseases --- Mediterranean Diet --- public health policy --- childhood obesity --- healthy lifestyle --- health communication --- n/a

The Molecular and Cellular Basis for Parkinson's Disease

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ISBN: 9783039215485 / 9783039215492 Year: Pages: 230 DOI: 10.3390/books978-3-03921-549-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:15
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The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Keywords

epigenetics --- Parkinson’s disease --- brain --- DNA methylation --- Parkinson’s disease --- fatty acid ?-oxidation --- long-chain acylcarnitine --- Parkinson’s disease --- fatty acyls --- glycerolipids --- glycerophospholipids --- sphingolipids --- sterol lipids --- lipoproteins --- ?-synuclein-mediated pathology --- disease-modifying effects --- neuroprotection --- autophagy --- cysteinyl-dopamine --- hypochlorite --- oxidative stress --- Parkinson’s disease --- redox cycling --- Parkinson’s disease --- brain iron --- motor dysfunction --- neurometabolites --- magnetic resonance imaging --- magnetic resonance spectroscopy --- GABA --- spectroscopy --- Parkinson’s disease --- neuroinflammation --- alpha-Synuclein --- immunotherapy --- mesenchymal stem cells --- secretome --- exosomes --- Parkinson’s disease --- microRNAs --- Parkinson disease --- multiprofessional therapy --- inpatient treatment --- multimodal complex treatment --- caffeic acid --- chlorogenic acid --- rotenone --- Parkinson’s disease --- neuroprotection --- dopaminergic neuron --- myenteric plexus --- enteric glial cell --- metallothionein --- Parkinson’s disease --- microbiota --- molecular mimicry --- microbiome --- alpha-synuclein --- curli --- gut-brain axis --- neurodegeneration --- glucocerebrosidase --- Parkinson’s disease --- Gaucher’s disease --- Lewy Body Dementia --- REM sleep behavior disorders --- [123I]FP-CIT-SPECT --- DAT --- nigral cells --- Parkinson’s disease --- parkinsonisms --- cell line --- differentiation --- HOG --- immature oligodendrocyte --- Krabbe’s disease --- oligodendrocyte --- mature oligodendrocyte --- MO3.13 --- myelin --- multiple sclerosis --- schizophrenia --- SH-SY5Y

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