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Biochemistry Laboratory Manual For Undergraduates. An Inquiry-Based Approach

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ISBN: 9783110411331 9783110426250 Year: Pages: 184 DOI: 10.2478/9783110411331 Language: English
Publisher: De Gruyter
Subject: Biochemistry
Added to DOAB on : 2015-04-13 10:35:26
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Biochemistry laboratory manual for undergraduates – an inquiry based approach by Gerczei and Pattison is the first textbook on the market that uses a highly relevant model, antibiotic resistance, to teach seminal topics of biochemistry and molecular biology while incorporating the blossoming field of bioinformatics. The novelty of this manual is the incorporation of a student-driven real real-life research project into the undergraduate curriculum. Since students test their own mutant design, even the most experienced students remain engaged with the process, while the less experienced ones get their first taste of biochemistry research. Inclusion of a research project does not entail a limitation: this manual includes all classic biochemistry techniques such as HPLC or enzyme kinetics and is complete with numerous problem sets relating to each topic.

Diagnostic, Prognostic and Predictive Biological Markers in Bladder Cancer – Illumination of a Vision

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ISBN: 9783038976349 9783038976356 Year: Pages: 202 DOI: 10.3390/books978-3-03897-635-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics --- Pathology --- Urology
Added to DOAB on : 2019-02-21 09:26:53
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This Special Issue has been introduced with the aim of offering the possibility to publish new research results from old and new pioneers in the field of bladder cancer basic research. While editing this Special Issue we learned that an enormous enthusiasm is necessary to go on in bladder cancer research. In our eyes, bladder cancer is on one hand a very heterogenous malignancy, which is what makes it so difficult to focus on only one bladder cancer marker in bladder cancer diagnostics and follow-up. On the other hand, it is very important to find prognostic and predictive factors for bladder cancer due to its high incidence and its enormous costs, as one of the most expensive malignancies in the world. Finding and developing new bladder cancer markers is still a very dynamic field. Because there are many of these markers, it is impossible to report all of them. This Special Issue attempts to highlight the role of bladder cancer markers in diagnosis, and the most important biomarkers that have been recently studied and reported. This Special Issue highlights some of the most important markers. Further determination of recurrence and progression markers will contribute to establishing better treatments for individual patients. Molecular staging of urological tumors will allow the selection of cases that will require systemic treatment. It is necessary and important to integrate basic and clinical research under the same objectives.

Update in Pediatric Neuro-Oncology

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ISBN: 9783038975397 9783038975403 Year: Pages: 138 DOI: 10.3390/books978-3-03897-540-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics --- Pediatrics --- Oncology
Added to DOAB on : 2019-01-28 10:38:34
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This Special Issue of Bioengineering explores topics in Pediatric Neuro-Oncology ranging from preclinical modeling to translational research and neurocognitive outcomes. The topics are as below. 1.Radiotherapy advances in pediatric brain tumors;2.Neurofibromatosis 1 and brain tumors in children;3.Molecular biology of pediatric gliomas and therapeutic insights;4.Embryonal tumors of the central nervous system in children-era of targeted therapeutics;5.Preclinical models in pediatric brain tumors—clinical relevance;6.Molecular neuroimaging of brain tumors;7.Palliative care for children with central nervous system malignancies;8.Neurocognitive and psychosocial outcomes following pediatric brain tumors.

Current Knowledge in Thyroid Cancer — From Bench to Bedside

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ISBN: 9783038424765 9783038424772 Year: Pages: VIII, 212 DOI: 10.3390/books978-3-03842-477-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-08-11 11:32:17
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In recent years, studies in the field of thyroid cancer have been performed in order to identify and verify thyroid specific biomarkers, as well as cancer-specific changes in gene expression patterns and alterations of the protein content. Furthermore, new drugs, small molecules and antibodies were developed and tested in vitro and in vivo. Trials investigated the ratio between therapeutic and adverse effects. Tyrosine kinase inhibitors (TKI) have become a new therapeutic option of both differentiated thyroid cancer and medullary thyroid cancer. In the last few years, new substances for targeted systemic therapy have been approved after their efficacy was demonstrated in Phase III trials. Most of them show a moderate response. However, adverse effects are common. TKI are used in patients with advanced metastatic thyroid cancer that is radioiodine (RAI)-refractory.In this Special Issue, original studies on the pathophysiology, diagnosis, and therapy of thyroid cancer, including genetics, proteomics, metabolomics, molecular and cell biology, will be published. It will also cover reports on patients, providing novel mechanistic insights into the underlying pathogenesis or new aspects that may impact clinical therapy, and recent study results in order to review the current status of new therapy options in thyroid cancer.

Food for Africa

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ISBN: 9781920499815 9781775820482 Year: Language: English
Publisher: UCT Press Grant: Knowledge Unlatched - 102948
Subject: History
Added to DOAB on : 2019-04-11 11:21:02
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Jennifer Thomson, one of the world’s leading scientific advisors on genetic engineering, traces through anecdote and science the development of a hotly contended area of research, from the dawn of genetic engineering in the USA in 1974, through the early stages of its uptake in South Africa to the current situation in which approximately 80% of maize in South Africa is genetically modified for drought resistance. Through her own story of how she came to choose GM as a career and her path-breaking involvement in the development of GM research, she describes the spread of this technology into other parts of Africa and her venture into unknown territory to develop crops resistant to drought, insects and viruses, a journey in which she came up against the multinational Monsanto. The book describes a remarkable personal and scientific evolution and looks to a future in which staple crops may be grown in difficult conditions by smallholder farmers and help Africans achieve food security.

Biological Activity of Natural Secondary Metabolite Products

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ISBN: 9783038971740 9783038971757 Year: Pages: 466 DOI: 10.3390/books978-3-03897-175-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social and Public Welfare --- Biology --- Anthropology
Added to DOAB on : 2018-09-20 12:02:36
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Natural secondary metabolite products, which are isolated from plants, animals, microorganisms, etc., are classified as polyketides, isoprenoids, aromatics (phenylpropanoids), alkaloids, etc. Their chemical diversity and variety of biological activities have attracted the attention of chemists, biochemists, biologists, etc. The Special Issue on "Biological Activity of Natural Secondary Metabolite Products" is intended to offer biological active natural products as candidates and/or leads for pharmaceuticals, dietary supplements, functional foods, cosmetics, food additives, etc. The research fields of this Special Issue include natural products chemistry, phytochemistry, pharmacognosy, food chemistry, bioorganic synthetic chemistry, chemical biology, molecular biology, molecular pharmacology, and other related research fields of bioactive natural secondary metabolite products. Original research and review articles on all topics in these research fields are invited. I am looking forward to receiving many submissions from outstanding experts in these research fields.

Inflammation and Cancer

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ISBN: 9783038426080 9783038426097 Year: Pages: VIII, 248 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-12-27 10:02:13
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Based on the most recent clinical and epidemiologic information, one out of seven newly diagnosed epithelial malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. This book draws contributions from international expert researchers from diverse disciplines, who addressed various aspects of experimental and clinical cancer biology, by selectively focusing on inflammation-mediated oncogenesis to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative/therapeutic strategies. This comprehensive and cutting-edge Special Issue “Inflammation and Cancer” promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of fighting the estimated 2200 inflammation-related oncogenesis fatalities occurring every day.

Molecular Mechanism of Alzheimer's Disease

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ISBN: 9783039214075 9783039214082 Year: Pages: 228 DOI: 10.3390/books978-3-03921-408-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Keywords

?-secretase --- amyloid beta --- calcium signaling --- drug target discovery --- endoplasmic reticulum --- inositol 1,4,5-trisphosphate receptor --- ion channel --- oxidative stress --- ryanodine receptor --- therapy --- amyloid-? oligomer --- protein aggregation --- A?O receptors --- Alzheimer’s disease --- neurodegeneration --- amyloid ? --- Alzheimer’s disease --- cognitive function --- dairy products --- dementia --- inflammation --- microglia --- Alzheimer’s disease --- yeast --- Tau --- amyloid ? --- ubiquitin --- aggregation --- oligomerization --- prion --- CDK5R1 --- lncRNAs --- Alzheimer’s disease --- miR-15/107 --- NEAT1 --- HOTAIR --- MALAT1 --- heat shock response --- heat shock protein --- Alzheimer’s disease --- beta amyloid --- yeast --- Alzheimer’s disease --- complement receptor 1 --- CR1 length polymorphism --- CR1 density --- complement C3b/C4b receptor --- complement --- dementia --- molecular biology --- neurosciences --- genetic risk --- Alzheimer’s disease --- brain glucose metabolism --- neuronal differentiation --- neuronal degeneration --- Prolyl isomerases --- Pin1 --- type 2 diabetes --- type 3 diabetes --- miR-34c --- dendritic spine --- Alzheimer’s disease --- Alzheimer’s disease --- positron emission tomography (PET) --- magnetic resonance imaging (MRI) --- Alzheimer’s disease --- cystathionine-?-lyase CTH gene --- DNA methylation --- epigenetics --- epigenome-wide association study --- methylome --- methylenetetrahydrofolate reductase MTHFR gene --- nutrition --- S-adenosylmethionine --- vitamin B complex --- Alzheimer’s disease --- sleep disturbance --- sleep fragmentation --- slow-wave sleep --- amyloid beta --- tau --- proteostasis --- default-mode network --- cognitive behavioral therapy for insomnia --- APOE gene --- apolipoprotein E --- DNA methylation --- mild cognitive impairment --- Hispanics

Synthetic DNA and RNA Programming

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ISBN: 9783039217342 9783039217359 Year: Pages: 188 DOI: 10.3390/books978-3-03921-735-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease.

Keywords

fluorescent reporter --- live cell imaging --- microRNA quantification --- optogenetics --- small molecule drug screening --- Escherichia coli --- recombinant protein production --- gene overexpression --- growth effect --- ASKA collection --- codon bias --- branched-chain amino acids --- gene ontology --- genetic code expansion --- protein kinase B --- phosphoinositide dependent kinase 1 --- phosphoseryl-tRNA synthetase --- tRNASep --- alanyl-tRNA synthetase --- class II aminoacyl-tRNA synthetase --- expanded genetic code --- lysine acetylation --- posttranslational modification --- genetic code expansion --- transfer RNA --- synthetic biology --- non-canonical amino acids --- selenocysteine --- genetic code expansion --- release factor 1 --- amber stop codon suppression --- M. jannaschii orthogonal pair --- fluorescence-based screen --- cyclic peptides --- biopharmaceuticals --- mRNA display --- yeast two hybrid --- tRNASer --- mistranslation --- anticodon --- functional conservation --- alternative amino acid and nucleotide repertoires --- alternative core cellular chemistries --- biocontainment --- genetic firewall --- genetic isolation --- orthogonal central dogma of molecular biology --- synthetic life --- xenobiology --- genome engineering --- synthetic biology --- yeasts --- Metschnikowia --- genetic tools --- DNA delivery --- CUG-Ser --- reverse polymerization --- tRNA editing --- tRNA repair --- protein engineering --- synthetic biology --- tRNA --- misacylation --- indirect tRNA aminoacylation --- AspRS --- GluRS-like --- genetic code expansion --- genome synthesis --- genome editing --- microRNA --- protein modification --- RNA metabolism --- tRNA --- synthetic biology --- unnatural amino acids --- unnatural nucleotides

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