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Personalized Medicine and Neurosurgery

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453368 Year: Pages: 133 DOI: 10.3389/978-2-88945-336-8 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Surgery
Added to DOAB on : 2018-02-27 16:16:45
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The Precision Medicine Initiative, which was instituted by President Barack Obama on January 20, 2015, highlighted the importance that advances in genomics and related “-omic” approaches have made to science and medicine, and it set the stage for their federally funded and mandated integration into the delivery of health care. Whether these advances comprise large-scale approaches, such as The Cancer Genome Atlas, which provides a modern classification of cancers based on molecular profiles, or genealogy initiatives, which seek to trace the movement of our early ancestors out of Africa, genomic technology has taken us closer to developing targeted therapies and a refined understanding of our evolutionary journey. It is against this backdrop that we summarized some of the recent advances in the field of precision medicine, or personalized medicine, as they pertain to neurosurgery. In this e-Book collection provided by Frontiers in Surgery: Neurosurgery, we present a collection of articles by leaders in the field of neurosurgery that highlight domains using a personalized approach for the treatment of patients or avenues when personalization is possible and when it will likely alter the care of patients with neurological diseases.

Animals and the Shaping of Modern Medicine

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Book Series: Medicine and Biomedical Sciences in Modern History ISBN: 9783319643366 9783319643373 Year: Pages: 290 DOI: 10.1007/978-3-319-64337-3 Language: English
Publisher: Springer Grant: Wellcome Trust
Subject: Medicine (General) --- History
Added to DOAB on : 2019-01-15 13:34:15
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This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological. Each chapter analyses an important episode in which animals changed and were changed by medicine. Ranging across the animal inhabitants of Britain’s zoos, sick sheep on Scottish farms, unproductive livestock in developing countries, and the tapeworms of California and Beirut, they illuminate the multi-species dimensions of modern medicine and its rich historical connections with biology, zoology, agriculture and veterinary medicine. The modern movement for One Health – whose history is also analyzed – is therefore revealed as just the latest attempt to improve health by working across species and disciplines. This book will appeal to historians of animals, science and medicine, to those involved in the promotion and practice of One Health today.


Keywords

Animals --- diseases --- medicine --- history

The Poetics and Politics of Alzheimer’s Disease Life-Writing

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Book Series: Palgrave Studies in Literature, Science and Medicine ISBN: 9783319443874 9783319443881 Year: Pages: 167 DOI: https://doi.org/10.1007/978-3-319-44388-1 Language: English
Publisher: Palgrave Macmillan
Subject: Neurology --- Internal medicine
Added to DOAB on : 2017-11-23 16:00:43
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This is the first book-length exploration of the thoughts and experiences expressed by dementia patients in published narratives over the last thirty years. It contrasts third-person caregiver and first-person patient accounts from different languages and a range of media, focusing on the poetical and political questions these narratives raise: what images do narrators appropriate; what narrative plot do they adapt; and how do they draw on established strategies of life-writing. It also analyses how these accounts engage with the culturally dominant Alzheimer’s narrative that centres on dependence and vulnerability, and addresses how they relate to discourses of gender and aging. Linking literary scholarship to the medico-scientific understanding of dementia as a neurodegenerative condition, this book argues that, first, patients’ articulations must be made central to dementia discourse; and second, committed alleviation of caregiver burden through social support systems and altered healthcare policies requires significantly altered views about aging, dementia, and Alzheimer’s patients.

The Impact of Systems Medicine on Human Health and Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451401 Year: Pages: 96 DOI: 10.3389/978-2-88945-140-1 Language: English
Publisher: Frontiers Media SA
Subject: Physiology --- Neurology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Complex diseases including diabetes, neurological disorders and cancer are results from a combination of genetic, environmental and lifestyle factors, and development of new prognostic tools for the treatment of such diseases requires a deep understanding of the mechanisms underlying cell functions. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models, as well as the developed tools, can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects. In this Research Topic, we aim to review the recently developed tools for modeling the cell behavior in normal and pathological states, recent advances and findings which increase our understanding of the molecular mechanisms involved in the progression of the diseases.

Interface Oral Health Science 2016: Innovative Research on Biosis–Abiosis Intelligent Interface

Authors: --- ---
ISBN: 9789811015595 9789811015601 Year: Pages: 277 DOI: 10.1007/978-981-10-1560-1 Language: English
Publisher: Springer
Subject: Manufactures --- Biotechnology --- Medicine (General) --- Dentistry --- Therapeutics
Added to DOAB on : 2017-03-08 13:39:59
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This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted “Interface Oral Health Science” several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014.This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines.

Innovative Radiopharmaceuticals in Oncology and Neurology

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451746 Year: Pages: 114 DOI: 10.3389/978-2-88945-174-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General)
Added to DOAB on : 2017-08-28 14:01:09
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The aim of this Research Topic was to assemble a series of articles describing basic, preclinical and clinical research studies on radiopharmaceuticals and nuclear medicine. The articles were written by attendees of the third Nuclear Technologies for Health Symposium (NTHS, 10th-11th March 2015, Nantes, Frances) under the auspices of the IRON LabEx (Innovative Radiopharmaceuticals for Oncology and Neurology Laboratory of Excellence). This French network, gathering approximately 160 scientists from 12 academic research teams (Funded by “investissements d’Avenir”), fosters transdisciplinary projects between teams with expertise in chemistry, radiochemistry, radiopharmacy, formulation, biology, nuclear medicine and medical physics. The 12 articles within this resulting eBook present a series of comprehensive reviews and original research papers on multimodality imaging and targeted radionuclide therapy; illustrating the different facets of studies currently conducted in these domains.

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