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The Foundation of Precision Medicine: Integration of Electronic Health Records with Nenomics Through Basic, Clinical, and Translational Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198726 Year: Pages: 194 DOI: 10.3389/978-2-88919-872-6 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.

Social Democratic Parties and the Working Class

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Book Series: Challenges to Democracy in the 21st Century ISBN: 9783030462390 Year: Pages: 111 DOI: 10.1007/978-3-030-46239-0 Language: English
Publisher: Springer Nature
Subject: Political Science --- Sociology
Added to DOAB on : 2020-09-01 00:03:35
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This open access book carefully explores the relationship between social democracy and its working-class electorate in Western Europe. Relying on different indicators, it demonstrates an important transformation in the class basis of social democracy. At the beginning of the twenty-first century, the working-class vote is strongly fragmented and social democratic parties face competition on multiple fronts for their core electorate – and not only from radical right parties. Starting from a reflection on ‘working-class parties’ and using a sophisticated class schema, the book paints a nuanced and diversified picture of the trajectory of social democracy that goes beyond a simple shift from working-class to middle-class parties. Following a detailed description, the book reviews possible explanations of workers' new voting patterns and emphasizes the crucial changes in parties' ideologies. It closes with a discussion on the role of the working class in social democracy's future electoral strategies.

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