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Chapter: 'Ten Theses on the Subject of Biology and Politics: Conceptual, Methodological, and Biopolitical Considerations' from book: The Palgrave Handbook of Biology and Society (Book chapter)

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ISBN: 9781137528780 9781137528797 Year: Pages: 26 DOI: https://doi.org/10.1057/978-1-137-52879-7_38 Language: English
Publisher: Palgrave Macmillan
Subject: Political Science --- Biology
Added to DOAB on : 2017-11-10 17:00:57
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In this chapter, I develop a set of concepts and methodological principles that researchers might draw on as they try to elucidate the processes by which the engagement of humans with their social worlds, material environments, and historical cultures results in the formation of a self in subject, corporeal, and biological dimensions. I forge a conceptual language and rules for analysis that may enable scholars to negotiate converging accounts of how the social norms, lived environments, and power relations through which people develop a sense of self are bound up with processes through which biological organisms compose and recompose themselves over time.

Keywords

biopolitics --- biology --- society

Metabolomics in the Analysis of Inflammatory Diseases (Book chapter)

Book title: Metabolomics

Authors: --- --- --- --- et al.
ISBN: 9789535100461 Year: DOI: 10.5772/31814 Language: English
Publisher: IntechOpen Grant: Wellcome Trust - 089384
Subject: Biology
Added to DOAB on : 2019-01-17 11:47:01
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Most infections and traumatic injuries are cleared or repaired relatively rapidly and metabolic homoeostasis is soon restored. However, there is a broad range of inflammatory&#xD;diseases which involve chronic activation of the immune system and, as a result, chronic&#xD;persistent inflammation. We have been studying the metabolic consequences of chronic&#xD;inflammatory diseases with the aim of identifying metabolic fingerprints which may&#xD;provide clues about why the localised tissue disease persists.

Central Immune Senescence, Reversal Potentials (Book chapter)

Book title: Senescence

Authors: ---
ISBN: 9789535101444 Year: Language: English
Publisher: IntechOpen Grant: Wellcome Trust - 079415
Subject: Biology
Added to DOAB on : 2019-01-17 11:47:01
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Ageing is a complex process that affects all living organisms. Senescence is not only conceivable in multicellular organisms, but also in unicellulars. Unlike certain diseases that&#xD;have specific morbidity rates, ageing is a physiological process that affects all individuals&#xD;that live long enough (unaffected by i.e. predation or famine) to experience senescence.

Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453337 Year: Pages: 142 DOI: 10.3389/978-2-88945-333-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology --- Biology
Added to DOAB on : 2018-11-16 17:17:57
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Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options.Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.

Make Life Visible

Authors: --- --- ---
ISBN: 9789811379086 Year: Pages: 292 DOI: 10.1007/978-981-13-7908-6 Language: English
Publisher: Springer
Subject: Biology --- Neurology --- Medicine (General)
Added to DOAB on : 2020-02-04 11:21:23
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This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completely impossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology in the broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license. ;

Bioimage Data Analysis Workflows

Authors: ---
Book Series: Learning Materials in Biosciences ISBN: 9783030223861 Year: Pages: 170 DOI: 10.1007/978-3-030-22386-1 Language: English
Publisher: Springer
Subject: Biology --- Medicine (General)
Added to DOAB on : 2020-02-04 11:21:06
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This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows. The textbook is chiefly intended for advanced undergraduates in the life sciences and biomedicine without a theoretical background in data analysis, as well as for postdocs, staff scientists and faculty members who need to perform regular quantitative analyses of microscopy images.

Quantitative Systems Biology for Engineering Organisms and Pathways

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198290 Year: Pages: 126 DOI: 10.3389/978-2-88919-829-0 Language: English
Publisher: Frontiers Media SA
Subject: Biotechnology --- General and Civil Engineering
Added to DOAB on : 2016-01-19 14:05:46
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Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different –omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluable information. Combination of experimental top-down and bottom-up approaches with powerful analytical tools/techniques and mathematical modeling, namely (quantitative) systems biology, currently making the state of art of this discipline, is the only practice that would improve our understanding for the purpose. The use of high-throughput technologies induced the required development of many bioinformatics tools and mathematical methods for the integration of obtained data. Such research is significant since compiling information from different levels of a living system and connecting them is not an easy task. In particular, construction of dynamic models for product improvement has been one of the goals of many research groups. In this Research Topic, we summarize and bring a general review of the most recent and relevant contributions in quantitative systems biology applied in metabolic modeling perspective. We want to make special emphasis on the techniques that can be widely implemented in regular scientific laboratories and in those works that include theoretical presentations. With this Research Topic we discuss the importance of applying systems biology approaches for finding metabolic engineering targets for the efficient production of the desired biochemical integrating information from genomes and networks to industrial production. Examples and perspectives in the design of new industrially relevant chemicals, e.g. increased titer/productivity/yield of (bio)chemicals, are welcome. Addition to the founded examples, potential new techniques that would frontier the research will be part of this topic. The significance of multi ‘omics’ approaches to understand/uncover the pathogenesis/mechanisms of metabolic diseases is also one of the main topics.

Metal Biology Takes Flight: The Study of Metal Homeostasis and Detoxification in Insects

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455560 Year: Pages: 144 DOI: 10.3389/978-2-88945-556-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
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Metals such as copper, iron, manganese, and zinc are clearly required for proper metabolism and development, while imbalances can lead to systemic dysfunction and disease. As a result, organisms have evolved complex genetic systems for the regulation of metal levels, including import, export, and sequestration of metals within cells and sub-cellular compartments.

The study of metal biology in insects has the potential to greatly expand our understanding of metal biology. The results of such studies might point to new possible therapeutic interventions for neurological and other human diseases, as well as new strategies for insect disease vector control.

The articles collected in this Research Topic comprise review and original research on metal biology in insects.

Evolutionary Genomics

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Book Series: Methods in Molecular Biology ISBN: 9781493990740 Year: Pages: 780 DOI: 10.1007/978-1-4939-9074-0 Language: English
Publisher: Springer
Subject: Biology
Added to DOAB on : 2020-01-29 11:21:11
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This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward.

Bird Species

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Book Series: Fascinating Life Sciences ISBN: 9783319916897 Year: Pages: 266 DOI: 10.1007/978-3-319-91689-7 Language: English
Publisher: Springer
Subject: Zoology --- Biology
Added to DOAB on : 2020-02-05 11:21:16
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The average person can name more bird species than they think, but do we really know what a bird “species” is? This open access book takes up several fascinating aspects of bird life to elucidate this basic concept in biology. From genetic and physiological basics to the phenomena of bird song and bird migration, it analyzes various interactions of birds – with their environment and other birds. Lastly, it shows imminent threats to birds in the Anthropocene, the era of global human impact. Although it seemed to be easy to define bird species, the advent of modern methods has challenged species definition and led to a multidisciplinary approach to classifying birds. One outstanding new toolbox comes with the more and more reasonably priced acquisition of whole-genome sequences that allow causative analyses of how bird species diversify. Speciation has reached a final stage when daughter species are reproductively isolated, but this stage is not easily detectable from the phenotype we observe. Culturally transmitted traits such as bird song seem to speed up speciation processes, while another behavioral trait, migration, helps birds to find food resources, and also coincides with higher chances of reaching new, inhabitable areas. In general, distribution is a major key to understanding speciation in birds. Examples of ecological speciation can be found in birds, and the constant interaction of birds with their biotic environment also contributes to evolutionary changes. In the Anthropocene, birds are confronted with rapid changes that are highly threatening for some species. Climate change forces birds to move their ranges, but may also disrupt well-established interactions between climate, vegetation, and food sources. This book brings together various disciplines involved in observing bird species come into existence, modify, and vanish. It is a rich resource for bird enthusiasts who want to understand various processes at the cutting edge of current research in more detail. At the same time it offers students the opportunity to see primarily unconnected, but booming big-data approaches such as genomics and biogeography meet in a topic of broad interest. Lastly, the book enables conservationists to better understand the uncertainties surrounding “species” as entities of protection.

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