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Cyber-Physical Systems of Systems: Foundations – A Conceptual Model and Some Derivations: The AMADEOS Legacy

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Book Series: Programming and Software Engineering ISSN: 0302-9743 ISBN: 9783319475899 9783319475905 Year: Volume: 10099 Pages: 257 DOI: 10.1007/978-3-319-47590-5 Language: English
Publisher: Springer Nature
Subject: General and Civil Engineering --- Electrical and Nuclear Engineering --- Computer Science --- Media and communication
Added to DOAB on : 2017-03-08 15:25:05
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Technical Systems-of-Systems (SoS) – in the form of networked, independent constituent computing systems temporarily collaborating to achieve a well-defined objective – form the backbone of most of today’s infrastructure. The energy grid, most transportation systems, the global banking industry, the water-supply system, the military equipment, many embedded systems, and a great number more, strongly depend on systems-of-systems. The correct operation and continuous availability of these underlying systems-of-systems are fundamental for the functioning of our modern society.The 8 papers presented in this book document the main insights on Cyber-Physical System of Systems (CPSoSs) that were gained during the work in the FP7-610535 European Research Project AMADEOS (acronym for Architecture for Multi-criticality Agile Dependable Evolutionary Open System-of-Systems). It is the objective of this book to present, in a single consistent body, the foundational concepts and their relationships. These form a conceptual basis for the description and understanding of SoSs and go deeper in what we consider the characterizing and distinguishing elements of SoSs: time, emergence, evolution and dynamicity.

Photonic Integration and Photonics-Electronics Convergence on Silicon Platform

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196937 Year: Pages: 109 DOI: 10.3389/978-2-88919-693-7 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Materials --- Science (General) --- Physics (General)
Added to DOAB on : 2016-08-16 10:34:25
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Silicon photonics technology, which has the DNA of silicon electronics technology, promises to provide a compact photonic integration platform with high integration density, mass-producibility, and excellent cost performance. This technology has been used to develop and to integrate various photonic functions on silicon substrate. Moreover, photonics-electronics convergence based on silicon substrate is now being pursued. Thanks to these features, silicon photonics will have the potential to be a superior technology used in the construction of energy-efficient cost-effective apparatuses for various applications, such as communications, information processing, and sensing. Considering the material characteristics of silicon and difficulties in microfabrication technology, however, silicon by itself is not necessarily an ideal material. For example, silicon is not suitable for light emitting devices because it is an indirect transition material. The resolution and dynamic range of silicon-based interference devices, such as wavelength filters, are significantly limited by fabrication errors in microfabrication processes. For further performance improvement, therefore, various assisting materials, such as indium-phosphide, silicon-nitride, germanium-tin, are now being imported into silicon photonics by using various heterogeneous integration technologies, such as low-temperature film deposition and wafer/die bonding. These assisting materials and heterogeneous integration technologies would also expand the application field of silicon photonics technology. Fortunately, silicon photonics technology has superior flexibility and robustness for heterogeneous integration. Moreover, along with photonic functions, silicon photonics technology has an ability of integration of electronic functions. In other words, we are on the verge of obtaining an ultimate technology that can integrate all photonic and electronic functions on a single Si chip. This e-Book aims at covering recent developments of the silicon photonic platform and novel functionalities with heterogeneous material integrations on this platform.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198153 Year: Pages: 191 DOI: 10.3389/978-2-88919-815-3 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

The Cellular Automaton Interpretation of Quantum Mechanics

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Book Series: Fundamental Theories of Physics ISSN: 0168-1222 ISBN: 9783319412849 9783319412856 Year: Pages: 298 DOI: 10.1007/978-3-319-41285-6 Language: English
Publisher: Springer Nature
Subject: Astronomy (General) --- Geology --- Earth Sciences --- Physics (General)
Added to DOAB on : 2017-02-14 10:09:28
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This book presents the deterministic view of quantum mechanics developed by Nobel Laureate Gerard 't Hooft.Dissatisfied with the uncomfortable gaps in the way conventional quantum mechanics meshes with the classical world, 't Hooft has revived the old hidden variable ideas, but now in a much more systematic way than usual. In this, quantum mechanics is viewed as a tool rather than a theory.The author gives examples of models that are classical in essence, but can be analysed by the use of quantum techniques, and argues that even the Standard Model, together with gravitational interactions, might be viewed as a quantum mechanical approach to analysing a system that could be classical at its core. He shows how this approach, even though it is based on hidden variables, can be plausibly reconciled with Bell's theorem, and how the usual objections voiced against the idea of ‘superdeterminism' can be overcome, at least in principle.This framework elegantly explains - and automatically cures - the problems of the wave function collapse and the measurement problem. Even the existence of an “arrow of time" can perhaps be explained in a more elegant way than usual. As well as reviewing the author’s earlier work in the field, the book also contains many new observations and calculations. It provides stimulating reading for all physicists working on the foundations of quantum theory.

Product Recommendations in E-Commerce Retailing Applications

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Book Series: Forschungsergebnisse der Wirtschaftsuniversitaet Wien ISBN: 9783631566220 Year: Pages: 222 DOI: 10.3726/b13971 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Business and Management
Added to DOAB on : 2019-01-15 13:32:22
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The book deals with product recommendations generated by information systems referred to as recommender systems. Recommender systems assist consumers in making product choices by providing recommendations of the range of products and services offered in an online purchase environment. The quantitative research study investigates the influence of psychographic and sociodemographic determinants on the interest of consumers in personalized online book recommendations. The author presents new findings regarding the interest in recommendations, importance of product reviews for the decision process, motives for submitting ratings as well as comments, and the delivery of recommendations. The results show that opinion seeking, opinion leading, domain specific innovativeness, online shopping experience, and age are important factors in respect of the interest in personalized recommendations.

Phytoalexins: Current Progress and Future Prospects

ISBN: 9783038420583 9783038420590 Year: Pages: 516 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-05-12 11:33:35
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Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. It is now clear that phytoalexins exhibit toxicity across much of the biological spectrum, prokaryotic and eukaryotic. Starting in the 1950s, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their structure, their biological activity as well as mechanisms of their synthesis and their catabolism by microorganisms. Elucidation of the biosynthesis of numerous phytoalexins has also permitted the use of molecular biology tools for the exploration of the genes encoding enzymes of their synthesis pathways and their regulators. This has led to potential applications for increasing plant resistance to diseases. Phytoalexins display an enormous diversity belonging to various chemical families such as isoflavones, isoflavanones, pterocarpans, isoflavans, flavanones, coumestans, furanoacetylenes, phenylpropanoids, steroid glycoalkaloids, norsesquiterpenoids/sesquiterpenoids, coumarins, diterpenes, ent-kaurane-related diterpenoids, acidic sesquiterpenoids, 3-deoxyanthocyanidins, naphthaldehydes, indoles and stilbenes.Research papers dealing with all aspects of phytoalexins, including structure elucidation; chemical synthesis; methods for phytoalexin analysis in plant extracts or biological fluids; biosynthesis studies including modulation of phytoalexin synthesis; engineering of phytoalexin biochemical pathways in plants and microbes; biological activities; structure/activity relationships; phytoalexin metabolism in planta and by micro-organisms; roles and ATP Binding Cassette (ABC) transporters or Multi-Drugs Efflux (MDE) transporters are welcome for inclusion in this Special Issue of Molecules. Review articles, particularly those dealing with the themes mentioned above are also particularly welcome for inclusion.

Dynamical Systems

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ISBN: 9783906980478 9783906980522 Year: Pages: 551 DOI: 10.3390/books978-3-906980-52-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-01-12 10:53:34
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Complex systems are pervasive in many areas of science integrated in our daily lives. Examples include financial markets, highway transportation networks, telecommunication networks, world and country economies, social networks, immunological systems, living organisms, computational systems and electrical and mechanical structures. Complex systems are often composed of a large number of interconnected and interacting entities, exhibiting much richer global scale dynamics than the properties and behavior of individual entities. Complex systems are studied in many areas of natural sciences, social sciences, engineering and mathematical sciences. This special issue therefore intends to contribute towards the dissemination of the multifaceted concepts in accepted use by the scientific community. We hope readers enjoy this pertinent selection of papers which represents relevant examples of the state of the art in present day research. [...]

30 years of the Comet Assay: an overview with some new insights

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196494 Year: Pages: 174 DOI: 10.3389/978-2-88919-649-4 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2016-08-16 10:34:25
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By means of this ‘Frontiers in Genetics’ research topic, we are celebrating 30 years of the Comet Assay. The first paper on this single-cell gel electrophoresis assay was published in 1984 by O. Ostling and K.J. Johanson (Biochem. Biophys. Res. Commun. Vol.123: 291-298). The comet assay is a versatile and sensitive method for measuring single - and double-strand breaks in DNA. By including lesion-specific enzymes in the assay, its range and sensitivity are greatly increased, but it is important to bear in mind that their specificity is not absolute. The comet assay (with and without inclusion of lesion-specific enzymes) is widely used as a biomarker assay in human population studies - primarily to measure DNA damage, but increasingly also to assess the capacity of cells for DNA repair. Ostling and Johanson (Biochem. Biophys. Res. Commun., 1984) were also the first to report experiments to measure DNA repair, by simply following the decrease of DNA damage over time after challenging cells with ionising radiation. However, this approach is time-consuming and laborious as it requires an extended period of cell culture and is therefore not ideal for biomonitoring studies, which typically require high-throughput processing of many samples. As an alternative approach, the in vitro comet-based repair assay was developed: a cell extract is incubated with a DNA substrate containing specific lesions, and DNA incisions accumulate. The in vitro comet-based repair assay has been modified and improved over the past decade: it was first devised to measure base excision repair of oxidised purines in lymphocytes (Collins et al., Mutagenesis, 2001), but has since been adapted for other lesions and thus other repair pathways, as well as being applied to tissue samples in addition to cell suspensions. Even after 30 years, the comet assay is still in a growth phase, with many new users each year. Many questions are repeatedly raised, which may seem to have self-evident answers, but clearly, it is necessary to reiterate them for the benefit of the new audience, and sometimes being forced to think again about old topics can shed new light. Different applications of the comet assay are discussed in this special issue, including: genotoxicity testing in different organisms, human biomonitoring, DNA repair studies, environmental biomonitoring and clinical studies. Furthermore, we consider and where possible answer questions, including the ones raised by Raymond Tice at the 8th International Comet Assay Workshop in Perugia (Italy 2009): What is the spectrum of DNA damage detected by the various versions of the comet assay?; What are the limitations associated with each application?; What should be done to standardize the assay for biomonitoring studies?; Can the comet assay be used to monitor changes in global methylation status?; What cell types are suitable for detecting genotoxic substances and their effects in vivo and in vitro?; Can the assay be fully automated?; and more. So this ‘Frontiers in Genetics’ research topic is written for the beginner as well as for the experienced users of the comet assay.

New directions in corpus-based translation studies

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Book Series: Translation and Multilingual Natural Language Processing ISBN: 9783944675831 Year: Volume: 1 Pages: 174 DOI: 10.26530/OAPEN_559833 Language: English
Publisher: Language Science Press
Subject: Linguistics
Added to DOAB on : 2015-06-04 15:00:51
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Corpus-based translation studies has become a major paradigm and research methodology and has investigated a wide variety of topics in the last two decades. The contributions to this volume add to the range of corpus-based studies by providing examples of some less explored applications of corpus analysis methods to translation research. They show that the area keeps evolving as it constantly opens up to different frameworks and approaches, from appraisal theory to process-oriented analysis, and encompasses multiple translation settings, including (indirect) literary translation, machine(-assisted) translation and the practical work of professional legal translators. The studies included in the volume also expand the range of application of corpus applications in terms of the tools used to accomplish the research tasks outlined.

Microbial Exopolysaccharides: From Genes to Applications

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198436 Year: Pages: 161 DOI: 10.3389/978-2-88919-843-6 Language: English
Publisher: Frontiers Media SA
Subject: Microbiology --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Microbial polysaccharides represent an attractive alternative to those from plants or macro algae. They can be produced from renewable sources including lignocellulosic waste streams. Their production does not depend on geographical constraints and/or seasonal limitations. Additionally the manipulation of biosynthetic pathways to enhance productivity or to influence the chemi-cal polysaccharide composition is comparatively easy in bacteria. Microbial exopolysaccharides represents a valuable resource of biogenic and biodegradable polymers, suitable to replace petro based polymers in various technical applications. Furthermore, biocompatible exopolysaccha-rides are very attractive in medical applications, such as drug delivery systems, use as vaccines or nanoparticles. This research topic will depict the status quo, as well as the future needs in the field of EPS and biofilm research. Starting from the unexplored diversity of microbial polysaccharide producers to production processes and possibilities for modifications, to enhance the already high number of functionalities based on the chemical structures. An overview of the recent and future applications will be given, and the necessity in unravelling the biosynthesis of microbial exopolysaccharide producers is depicted, highlighting the future trend of tailor made polymers. Constraints in structure analysis of these highly complex biogenic polymers are described and different approaches to solve the restrictions in imaging and NMR analysis will be given. Therefore; this research topic comprises the whole process from genes to applications.

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