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Innovative Medicine: Basic Research and Development

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ISBN: 9784431556503 9784431556510 Year: Pages: 339 DOI: 10.1007/978-4-431-55651-0 Language: English
Publisher: Springer
Subject: Medicine (General)
Added to DOAB on : 2016-06-30 12:46:49
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This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Medicine, Religion and Gender in Medieval Culture

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ISBN: 9781843844013 Year: Pages: 310 DOI: 10.26530/OAPEN_574130 Language: English
Publisher: Boydell & Brewer Grant: Wellcome Trust - 097469
Subject: Medicine (General) --- Languages and Literatures
Added to DOAB on : 2015-08-30 11:01:12

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Current preoccupations with the body have led to a growing interest in the intersections between religion, literature and the history of medicine, and, more specifically, how they converge within a given culture. This collection of essays explores the ways in which aspects of medieval culture were predicated upon an interaction between medical and religious discourses, particularly those inflected by contemporary gendered ideologies. The essays interrogate this convergence broadly in a number of different ways: textually, conceptually, historically, socially and culturally. They argue for an inextricable relationship between the physical and spiritual in accounts of health, illness and disability, and demonstrate how medical, religious and gender discourses were integrated in medieval culture. Naoë Kukita Yoshikawa is Professor of English in the Faculty of Humanities and Social Sciences at Shizuoka University.&#xD;&#xD;Contributors: Louise M. Bishop, Elma Brenner, Joy Hawkins, Roberta Magnani, Takami Matsuda, Liz Herbert McAvoy, Irina Metzler, Denis Renevey, Patricia Skinner, Juliette Vuille, Diane Watt, Naoë Kukita Yoshikawa.

Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease

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ISBN: 9781783741182 9781783741199 Year: Pages: 244 DOI: 10.11647/OBP.0055 Language: English
Publisher: Open Book Publishers
Subject: Medicine (General)
Added to DOAB on : 2015-06-10 13:31:46
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Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.

The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195435 Year: Pages: 140 DOI: 10.3389/978-2-88919-543-5 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
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Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic chemotherapies have been used to treat metastatic NSCLC for decades, but the improvements of outcomes have reached a plateau. Recent advances in understanding signalling pathways for malignant cells, their interconections,the importance of various receptors and biomarkers and the interplay between various oncogenes have led to the development of targeted treatments that are improving both efficacy and safety of the treatments. Knowledge about the advantages of treatments with the targeted agents in metastatic NSCLC is growing rapidly. Combining various targeted agents or sequencing them properly will be important in the era of personalised medicine and overcoming development of the resistence to various targeted agents will be challenging. The importance of a team work,from the diagnosis through various treatments, to supportive care, from the interventional radiologists, pneumologists or surgeons, who have to obtain a satisfactory tumor tissue specimen, to pathologists, radiation and medical oncologists, to supportive care specialists, will be described in our publications. We will cover completely present and future approaches to personalised medicine in this rapidly evolving field of metastatic NSCLC.

Pediatric Integrative Medicine: An Emerging Field of Pediatrics

ISBN: 9783038420620 9783038420637 Year: Pages: 172 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2015-10-22 07:30:21
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Pediatric integrative medicine is a specialty that blends conventional medicine with evidence-based complementary therapies. Research shows that use of integrative medicine is common in children, especially in those living with chronic illness. Knowledge in several important areas of pediatric integrative medicine has expanded exponentially over the last decade. Despite this progress, many pediatricians and practitioners who work with children remain unaware of developments in this field.The goal of this special issue is to: define pediatric integrative medicine in its modern context, provide a history of the field’s evolution, highlight areas where research for its use in children is most robust at this time, and identify areas where research is lacking or evolving. Models of the use of integrative medicine in clinical pediatrics will be examined. Bioethics, informed consent, and provider credentialing will be discussed.Some of the most exciting clinical applications of integrative medicine in pediatrics include the use of mind-body medicine therapies such as guided imagery, hypnosis, and biofeedback for the treatment of pain. Mitigation of toxic stress and its health manifestations in children are another area of great potential application of the mind-body therapies. Other areas include integrative approaches to chronic illness, such as cancer, asthma, arthritis, bowel disease, and other chronic conditions where conventional therapies are necessary, yet leave treatment gaps that can be filled with evidence-based integrative therapies targeting lifestyle elements such as nutrition, sleep, physical activity, and social support that are often overlooked in this patient population. Integrative approaches have great potential in preventative heath. Conditions such as obesity and the metabolic syndrome affect a sobering number of children across all age ranges. Few successful treatment models exist for this patient population. Healthy lifestyle measures learned early in life can be a critical factor in providing a foundation for lifelong health for the child and family. Successful models for the use of integrative medicine in these patient populations are needed and will be explored.

Para-States and Medical Science: Making African Global Health

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Book Series: Critical Global Health: Evidence, Efficacy, Ethnography ISBN: 9780822357490 Year: Pages: 376 DOI: 10.26530/OAPEN_530530 Language: English
Publisher: Duke University Press Grant: Wellcome Trust - 077430, 081507
Subject: Public Health --- Medicine (General) --- Sociology --- Social Sciences
Added to DOAB on : 2015-03-20 11:01:17
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In Para-States and Medical Science, P. Wenzel Geissler and the contributors examine how medicine and public health in Africa have been transformed as a result of economic and political liberalization and globalization, intertwined with epidemiological and technological changes. The resulting fragmented medical science landscape is shaped and sustained by transnational flows of expertise and resources. NGOs, universities, pharmaceutical companies and other nonstate actors now play a significant role in medical research and treatment. But as the contributors to this volume argue, these groups have not supplanted the primacy of the nation-state in Africa. Although not necessarily stable or responsive, national governments remain crucial in medical care, both as employers of health care professionals and as sources of regulation, access, and – albeit sometimes counterintuitively - trust for their people. “The state” has morphed into the “para-state” — not a monolithic and predictable source of sovereignty and governance, but a shifting, and at times ephemeral, figure. Tracing the emergence of the “global health” paradigm in Africa in the treatment of HIV, malaria, and leprosy, this book challenges familiar notions of African statehood as weak or illegitimate by elaborating complex new frameworks of governmentality that can be simultaneously functioning and dysfunctional.

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africa --- medicine --- public health

The Territory of Medical Research: Experimentation in Africa’s Smallest State (Book chapter)

Book title: Para-States and Medical Science: Making African Global Health

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Book Series: Critical Global Health: Evidence, Efficacy, Ethnography ISBN: 9780822357353 9780822357490 Year: Pages: 376 Language: English
Publisher: Duke University Press Grant: Wellcome Trust - 077430, 081507
Subject: Public Health --- Medicine (General) --- Sociology --- Social Sciences
Added to DOAB on : 2018-06-22 11:01:04
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In Para-States and Medical Science, P. Wenzel Geissler and the contributors examine how medicine and public health in Africa have been transformed as a result of economic and political liberalization and globalization, intertwined with epidemiological and technological changes. The resulting fragmented medical science landscape is shaped and sustained by transnational flows of expertise and resources. NGOs, universities, pharmaceutical companies and other nonstate actors now play a significant role in medical research and treatment. But as the contributors to this volume argue, these groups have not supplanted the primacy of the nation-state in Africa. Although not necessarily stable or responsive, national governments remain crucial in medical care, both as employers of health care professionals and as sources of regulation, access, and – albeit sometimes counterintuitively - trust for their people. “The state” has morphed into the “para-state” — not a monolithic and predictable source of sovereignty and governance, but a shifting, and at times ephemeral, figure. Tracing the emergence of the “global health” paradigm in Africa in the treatment of HIV, malaria, and leprosy, this book challenges familiar notions of African statehood as weak or illegitimate by elaborating complex new frameworks of governmentality that can be simultaneously functioning and dysfunctional.

Keywords

africa --- medicine --- public health

Introduction: A Life Science in Its African Para-State (Book chapter)

Book title: Para-States and Medical Science: Making African Global Health

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Book Series: Critical Global Health: Evidence, Efficacy, Ethnography ISBN: 9780822357353 9780822357490 Year: Pages: 376 Language: English
Publisher: Duke University Press Grant: Wellcome Trust - 077430, 081507
Subject: Public Health --- Medicine (General) --- Sociology --- Social Sciences
Added to DOAB on : 2018-06-22 11:01:04
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In Para-States and Medical Science, P. Wenzel Geissler and the contributors examine how medicine and public health in Africa have been transformed as a result of economic and political liberalization and globalization, intertwined with epidemiological and technological changes. The resulting fragmented medical science landscape is shaped and sustained by transnational flows of expertise and resources. NGOs, universities, pharmaceutical companies and other nonstate actors now play a significant role in medical research and treatment. But as the contributors to this volume argue, these groups have not supplanted the primacy of the nation-state in Africa. Although not necessarily stable or responsive, national governments remain crucial in medical care, both as employers of health care professionals and as sources of regulation, access, and – albeit sometimes counterintuitively - trust for their people. “The state” has morphed into the “para-state” — not a monolithic and predictable source of sovereignty and governance, but a shifting, and at times ephemeral, figure. Tracing the emergence of the “global health” paradigm in Africa in the treatment of HIV, malaria, and leprosy, this book challenges familiar notions of African statehood as weak or illegitimate by elaborating complex new frameworks of governmentality that can be simultaneously functioning and dysfunctional.

Keywords

africa --- medicine --- public health

What Future Remains? Remembering an African Place of Science (Book chapter)

Book title: Para-States and Medical Science: Making African Global Health

Author:
Book Series: Critical Global Health: Evidence, Efficacy, Ethnography ISBN: 9780822357353 9780822357490 Year: Pages: 376 Language: English
Publisher: Duke University Press Grant: Wellcome Trust - 077430, 081507
Subject: Public Health --- Medicine (General) --- Sociology --- Social Sciences
Added to DOAB on : 2018-06-22 11:01:04
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In Para-States and Medical Science, P. Wenzel Geissler and the contributors examine how medicine and public health in Africa have been transformed as a result of economic and political liberalization and globalization, intertwined with epidemiological and technological changes. The resulting fragmented medical science landscape is shaped and sustained by transnational flows of expertise and resources. NGOs, universities, pharmaceutical companies and other nonstate actors now play a significant role in medical research and treatment. But as the contributors to this volume argue, these groups have not supplanted the primacy of the nation-state in Africa. Although not necessarily stable or responsive, national governments remain crucial in medical care, both as employers of health care professionals and as sources of regulation, access, and – albeit sometimes counterintuitively - trust for their people. “The state” has morphed into the “para-state” — not a monolithic and predictable source of sovereignty and governance, but a shifting, and at times ephemeral, figure. Tracing the emergence of the “global health” paradigm in Africa in the treatment of HIV, malaria, and leprosy, this book challenges familiar notions of African statehood as weak or illegitimate by elaborating complex new frameworks of governmentality that can be simultaneously functioning and dysfunctional.

Keywords

africa --- medicine --- public health

Muscle Cell and Tissue

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Book Series: 2015-09-02 ISBN: 9789535121565 9789535142188 Year: Pages: 486 DOI: 10.5772/59347 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:49

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In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.

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