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Quantitative Assessment and Validation of Network Inference Methods in Bioinformatics

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194780 Year: Pages: 191 DOI: 10.3389/978-2-88919-478-0 Language: English
Publisher: Frontiers Media SA
Subject: Biotechnology --- General and Civil Engineering --- Genetics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:33
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Scientists today have access to an unprecedented arsenal of high-tech tools that can be used to thoroughly characterize biological systems of interest. High-throughput “omics” technologies enable to generate enormous quantities of data at the DNA, RNA, epigenetic and proteomic levels. One of the major challenges of the post-genomic era is to extract functional information by integrating such heterogeneous high-throughput genomic data. This is not a trivial task as we are increasingly coming to understand that it is not individual genes, but rather biological pathways and networks that drive an organism’s response to environmental factors and the development of its particular phenotype. In order to fully understand the way in which these networks interact (or fail to do so) in specific states (disease for instance), we must learn both, the structure of the underlying networks and the rules that govern their behavior. In recent years there has been an increasing interest in methods that aim to infer biological networks. These methods enable the opportunity for better understanding the interactions between genomic features and the overall structure and behavior of the underlying networks. So far, such network models have been mainly used to identify and validate new interactions between genes of interest. But ultimately, one could use these networks to predict large-scale effects of perturbations, such as treatment by multiple targeted drugs. However, currently, we are still at an early stage of comprehending methods and approaches providing a robust statistical framework to quantitatively assess the quality of network inference and its predictive potential. The scope of this Research Topic in Bioinformatics and Computational Biology aims at addressing these issues by investigating the various, complementary approaches to quantify the quality of network models. These “validation” techniques could focus on assessing quality of specific interactions, global and local structures, and predictive ability of network models. These methods could rely exclusively on in silico evaluation procedures or they could be coupled with novel experimental designs to generate the biological data necessary to properly validate inferred networks.

Biomarkers of Alzheimer's Disease: The Present and the Future

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450411 Year: Pages: 218 DOI: 10.3389/978-2-88945-041-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2018-02-27 16:16:44
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Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the diagnosis in prodromal stage of the disease and to propose personalized therapeutic solutions to individual patients. New revised AD diagnostic criteria include early alteration of cerebrospinal fluid (CSF) biomarkers: decrease of amyloïd peptides (Aß42), and increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for the diagnosis of AD is a major step towards the “molecular” diagnosis and follow-up of the disease. Many issues are however still subject of debate. This e-book provides a comprehensive overview of the state of the art of fluid biomarkers for AD, e.g. which novel biomarkers should be implemented in clinical practice for diagnosis or for monitoring treatment or side effects, which ones are new for AD or related dementias or what is the potential of peripheral blood markers. Moreover, the e-Book provides practical guidelines how to optimally and efficiently develop and validate novel biomarker assays, and to document and control pre-analytical variation.

Modelling the bird flight : Scientific Report 2007-2010

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ISBN: 9783866447615 Year: Pages: 44 p. DOI: 10.5445/KSP/1000020294 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:02:00
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The aerodynamics of flying birds and insects plays a crucial role in the domain of aeronautical engineering. The energy-efficient construction of winglets for airplanes, the formation flight of tactical aircraft or the drone engineering or military applications are inspired by birds. This holds also for flow and structure simulation of flapping wing motion, taking the unsteady aerodynamics and corresponding wing deformations into account at high flow velocities and flapping frequencies.

The Role of Play in Child Assessment and Intervention

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452590 Year: Pages: 150 DOI: 10.3389/978-2-88945-259-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2018-02-27 16:16:44
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Play is a ubiquitous and universal aspect of early childhood. Although it may take different forms throughout development and across cultures, decades of research have found play to be related to important, positive outcomes. Play provides children with valuable cognitive, emotional, and interpersonal learning opportunities. It can act as a mode of communication for young children and allows them to practice ways of managing complex interpersonal interactions. Specific aspects of play, such as children’s creativity in pretend play, have been associated with resilience and coping. The significance of play in childhood has led to its frequent use in the assessment of child development and in the implementation of child and parent-child psychological and educational interventions. Historically, however, the validity and efficacy of these interventions have not been rigorously evaluated. Further, few assessment and intervention models have included parents, teachers, and other key caregivers, but have focused only on the child. This Research Topic will bring together the most current literature on the use of play in child assessment and intervention.

Current Aspects of Radiopharmaceutical Chemistry

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ISBN: 9783038971627 9783038971634 Year: Pages: 216 DOI: 10.3390/books978-3-03897-163-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Chemistry (General)
Added to DOAB on : 2018-09-19 11:46:43
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Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging techniques which are widely used in nuclear medicine for the diagnosis and treatment follow-up of many major diseases. They use biomolecules as probes, which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. Their design and development require a rather interdisciplinary process involving many different disciplines of natural and health sciences. In addition to their diagnostic and therapeutic purposes in the field of nuclear medicine, radiopharmaceuticals provide powerful tools for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets, investigate the pathophysiology of diseases, discover potential drug candidates, and evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. Furthermore, they allow molecular imaging studies in various small-animal models of disease, including genetically engineered animals. The current collection of articles provides unique examples covering all major aspects in the field.

Selenium Isotope Studies in Plants - Development and Validation of a Novel Geochemical Tool and its Application to Organic Samples

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Book Series: Karlsruher mineralogische und geochemische Hefte : Schriftenreihe des Instituts für Angewandte Geowissenschaften ISSN: 16182677 ISBN: 9783731505945 Year: Volume: 42 Pages: XXV, 223 p. DOI: 10.5445/KSP/1000060292 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Ethnology
Added to DOAB on : 2019-07-30 20:02:00
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Selenium (Se), being an essential nutrient and a toxin, enters the food chain mainly via plants. Selenium isotope signatures were proved to be an excellent redox tracer, making it a promising tool for the exploration of the Se cycle in plants. The analytical method is sensitive on organic samples and requires particular preparation methods, which were developed and validated in this study. Plant cultivation setups revealed the applicability of these methods to trace plant internal processes.

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