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Novel Approaches to the Analysis of Family Data in Genetic Epidemiology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199327 Year: Pages: 84 DOI: 10.3389/978-2-88919-932-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2016-01-19 14:05:46
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Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.

MaxEnt 2019—Proceedings, 2019, MaxEnt 2019The 39th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering

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ISBN: 9783039284764 9783039284771 Year: Pages: 312 DOI: 10.3390/books978-3-03928-477-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2020-04-07 23:07:09
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This Proceedings book presents papers from the 39th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering, MaxEnt 2019. The workshop took place at the Max Planck Institute for Plasma Physics in Garching near Munich, Germany, from 30 June to 5 July 2019, and invited contributions on all aspects of probabilistic inference, including novel techniques, applications, and work that sheds new light on the foundations of inference. Addressed are inverse and uncertainty quantification (UQ) and problems arising from a large variety of applications, such as earth science, astrophysics, material and plasma science, imaging in geophysics and medicine, nondestructive testing, density estimation, remote sensing, Gaussian process (GP) regression, optimal experimental design, data assimilation, and data mining.

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