Recent Progress in Solid Dispersion Technology
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https://mdpi.com/books/pdfview/book/1607Author(s)
Kawakami, Kohsaku
Language
EnglishAbstract
Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
Keywords
thermodynamic modeling; molecular dynamics simulation; poorly soluble drugs; amorphous solid dispersions; dissolution enhancement; crystallization tendency; continuous processing; stability; milling; granulation; thermal analysis; amorphous; ball milling; pharmaceutical glass; dissolution; rebamipide; poloxamer; classification; polyelectrolytes; amorphisation; self-assembly; dissolution rate; miscibility; bioavailability; solubility; evaporation; mesoporous; polyelectrolyte excipient matrix; polymer; bicaludamide; phase diagram; Weibull dissolution model; spectroscopic techniques; anticancer drugs; manufacturing methods; nucleation; molecular complex; nanoaggregates; enrofloxacin; accelerated stability test; solubility enhancement; amorphous solid dispersion; tadalafil; process development; amorphous polymeric salt; Wood’s apparatus; hot melt extrusion; solid dispersions; intrinsic dissolution rate; solid dispersion; interaction; crystallization; spray drying; characterization; ciprofloxacinISBN
9783039215010, 9783039215027Publisher website
www.mdpi.com/booksPublication date and place
2019Classification
Biology, life sciences