TY - BOOK ID - 44742 TI - Iron as Therapeutic Targets in Human Diseases Volume 1 AU - Arosio, Paolo AU - Poli, Maura AU - Gozzelino, Raffaella PY - 2020 SN - 9783039280827 9783039280834 DB - DOAB KW - cinnamic acid derivatives KW - soybean seed ferritin KW - iron release KW - binding ability KW - Fe2+-chelating activity KW - reducibility KW - adverse event profile KW - anaemia KW - bioengineering KW - labile iron KW - intravenous iron KW - iron-carbohydrate complex KW - iron processing KW - iron metabolism KW - infection KW - innate immunity KW - hepcidin KW - ferritin KW - anemia of inflammation KW - pharmaceutical targets KW - iron deficiency anemia KW - nutrient iron KW - oral iron therapy KW - FeSO4 KW - NaFeEDTA KW - non-transferrin-bound iron (NTBI) KW - developing countries KW - Indonesia KW - neurodegeneration KW - mitochondria KW - therapy KW - heme KW - haem KW - Iron-sulfur KW - Friedreich Ataxia KW - Oxidative stress KW - Iron chelators KW - iron deficiency KW - anemia KW - cancer KW - hepcidin KW - patient blood management KW - malaria KW - iron deficiency KW - hepcidin KW - TNF KW - children KW - Africa KW - Anemia KW - iron deficiency KW - oral iron salts KW - intravenous iron KW - Sucrosomial® iron KW - M cells KW - bioavailability KW - tolerability KW - efficacy KW - iron KW - gut microbiota KW - iron supplementation KW - iron transporters KW - mucosal immunity KW - SCFA KW - intestinal inflammation KW - inflammatory bowel disease (IBD) KW - colorectal cancer KW - oxidative stress KW - anaemia KW - cardiovascular disease KW - chronic kidney disease KW - IV iron therapy KW - bone homeostasis KW - iron overload KW - iron deficiency KW - osteoclast KW - osteoblast KW - osteoporosis KW - neurodegeneration with brain iron accumulation KW - iron chelation therapy KW - multifunctional iron chelators KW - fluorescent iron chelator KW - 3-hydroxy-4-pyridinone KW - fluorophore KW - rhodamine KW - membrane interactions KW - bacteria KW - antibacterial activity KW - histidine KW - iron KW - anemia KW - oxidative stress KW - kidney KW - chelation KW - iron KW - retina KW - age-related macular degeneration (AMD) KW - iron KW - lipid KW - obesity KW - cancer KW - neurodegeneration KW - iron chelation KW - phlebotomy KW - NCOA4 KW - ferritinophagy KW - iron homeostasis KW - erythropoiesis KW - ferroptosis KW - cancer KW - Tfr2 KW - iron metabolism KW - hepcidin KW - erythropoiesis KW - SNC KW - ferritin KW - iron mobilization KW - chaotropes KW - flavin nucleotide KW - electron transfer KW - kinetics KW - ferritin KW - iron KW - iron delivery KW - nanotechnology KW - nanocage KW - drug delivery KW - inflammation KW - serum biomarker KW - iron metabolism KW - hepcidin KW - ferroportin KW - hemochromatosis KW - anemia KW - hepcidin KW - iron deficiency anemia KW - iron dextran KW - neonatal period KW - pig KW - supplementation KW - Alzheimer’s disease KW - neuroinflammation KW - neurodegeneration KW - cytokines KW - neuroimmune responses KW - iron KW - genetic hemochromatosis KW - non transferrin bound iron KW - hepcidin KW - ferroportin KW - venesections KW - Anemia of chronic disease KW - anemia of inflammation KW - hepcidin KW - anti-hepcidin therapy KW - iron supplementation KW - macrophage KW - central nurse macrophage KW - red pulp macrophage KW - Kupffer cell KW - iron metabolism KW - erythropoiesis KW - erythroblastic islands KW - erythrophagocytosis KW - inflammation KW - iron homeostasis KW - lung diseases KW - oxygen sensing KW - hypoxia KW - ferritin KW - hereditary hyperferritinemia KW - hereditary hypoferritinemia KW - iron metabolism KW - cataracts syndrome KW - neurodegenerative disease KW - n/a KW - iron KW - neurodegeneration KW - NBIA KW - hepcidin KW - iron KW - lung KW - acute lung injury KW - COPD KW - lung infection KW - cystic fibrosis KW - iron KW - anaemia KW - infection KW - malaria KW - immunity KW - brain development KW - growth KW - microbiome KW - hepcidin KW - ferritin KW - iron supplementation KW - infants KW - children KW - low and middle income countries KW - liver KW - iron KW - hepcidin KW - Mek/Erk KW - Hfe KW - Bmp/Smad KW - iron KW - mycobacteria KW - immunity KW - Alzheimer’s disease KW - iron homeostasis KW - ferroptosis KW - senescence KW - chelators KW - macrophages KW - iron KW - metabolism KW - inflammation KW - iron KW - ferritin KW - acute kidney injury KW - chronic kidney disease KW - vascular calcification KW - iron KW - hepcidin KW - ferroportin KW - Interleukin-6 KW - infection KW - rheumatoid arthritis KW - iron homeostasis KW - iron absorption KW - non-haem iron KW - flavonoids KW - developmental KW - iron deficiency anemia KW - neonatal KW - transferrin receptor KW - treatment KW - hemochromatosis KW - HFE KW - natural history KW - T lymphocytes KW - MHC KW - CD8+ T cells KW - prevention KW - iron homeostasis KW - hepcidin KW - protein binding KW - peritoneal dialysis KW - iron KW - hepcidin KW - iron regulatory proteins KW - cardiomyocyte KW - chronic heart failure KW - pulmonary arterial smooth muscle cells KW - pulmonary arterial hypertension KW - iron KW - brain KW - neurophysiology KW - cognition KW - social behavior KW - didox KW - iron chelators KW - antitumor compound KW - iron metabolism KW - RRM2 KW - SLC40A1 KW - ferroportin KW - iron overload KW - non-HFE KW - ferritin KW - hemochromatosis KW - iron KW - chelation KW - neurodegenerative diseases KW - pituitary KW - brain KW - hemopexin KW - heme homeostasis KW - iron homeostasis KW - hemolysis KW - haptoglobin KW - ferroptosis KW - inflammation KW - biomarker KW - heme oxygenase KW - liver KW - microbiome KW - trauma KW - hemorrhage KW - iron metabolism KW - hepcidin KW - iron homeostasis KW - ferroportin KW - n/a UR - https://www.doabooks.org/doab?func=search&query=rid:44742 AB - Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions. ER -